LAB963
Collect
Green (sodium or lithium heparin). Collect on ice.
Patient Preparation
Patient should be calm and supine for 30 minutes prior to collection.
Specimen Preparation
Specimen should be centrifuged and frozen within one hour (refrigerated centrifuge is preferred but not required). Transfer 4 mL plasma to an ARUP Standard Transport
Tube. (Min: 2.1 mL)
Tube. (Min: 2.1 mL)
Unacceptable Conditions
EDTA plasma, serum, or urine.
Storage/Transport Temperature
Plain green and PST are both acceptable.
Stability (from collection to initiation)
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen at -20°C: 1 month; Frozen at -70°C: 1 year
Notes
Medications that may interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, labetalol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effect of drugs on catecholamine results may not be predictable.
For optimum results, patient should be supine for 30 minutes prior to collection.
Children, particularly those under 2 years of age, often show an elevated catecholamine response to stress.
For optimum results, patient should be supine for 30 minutes prior to collection.
Children, particularly those under 2 years of age, often show an elevated catecholamine response to stress.
Performed
Sun, Tue-Sat
Methodology
Quantitative High Performance Liquid Chromatography
Reported
1-3 days
Synonyms
- Epinephrine, Plasma
- Noradrenaline, Plasma
- Norepinephrine, Plasma
- Plasma Catecholamines
- Dopamine, Plasma
- Adrenalin, Plasma
- LAB963
Ordering Recommendations
Not recommended for evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma and paraganglioma, refer to Metanephrines, Plasma (Free) (0050184) or Metanephrines Fractionated by HPLC-MS/MS, Urine (2007996).
Reference Interval
Supine
Components | Reference Interval | ||||
---|---|---|---|---|---|
Epinephrine |
| ||||
Norepinephrine |
| ||||
Dopamine | 2 days and older: 0-20 pg/mL |
Interpretive Data
Small increases in catecholamines (less than 2 times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (2 or more times the upper reference limit) is associated with an increased
probability of a neuroendocrine tumor. Measurement of plasma or urine fractionated metanephrines provides better diagnostic sensitivity than measurement of catecholamines.
Higher catecholamine concentrations are observed in specimens collected from upright or standing adults. Epinephrine may be increased by approximately 20 percent; norepinephrine up to 700 pg/mL; dopamine, unchanged.
probability of a neuroendocrine tumor. Measurement of plasma or urine fractionated metanephrines provides better diagnostic sensitivity than measurement of catecholamines.
Higher catecholamine concentrations are observed in specimens collected from upright or standing adults. Epinephrine may be increased by approximately 20 percent; norepinephrine up to 700 pg/mL; dopamine, unchanged.
CPT Codes
82384
Collection |
LAB963
Collect
Green (sodium or lithium heparin). Collect on ice.
Patient Preparation
Patient should be calm and supine for 30 minutes prior to collection.
Specimen Preparation
Specimen should be centrifuged and frozen within one hour (refrigerated centrifuge is preferred but not required). Transfer 4 mL plasma to an ARUP Standard Transport
Tube. (Min: 2.1 mL)
Tube. (Min: 2.1 mL)
Unacceptable Conditions
EDTA plasma, serum, or urine.
Storage/Transport Temperature
Plain green and PST are both acceptable.
Stability (from collection to initiation)
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen at -20°C: 1 month; Frozen at -70°C: 1 year
Notes
Medications that may interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, labetalol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effect of drugs on catecholamine results may not be predictable.
For optimum results, patient should be supine for 30 minutes prior to collection.
Children, particularly those under 2 years of age, often show an elevated catecholamine response to stress.
For optimum results, patient should be supine for 30 minutes prior to collection.
Children, particularly those under 2 years of age, often show an elevated catecholamine response to stress.
Ordering |
Performed
Sun, Tue-Sat
Methodology
Quantitative High Performance Liquid Chromatography
Reported
1-3 days
Synonyms
- Epinephrine, Plasma
- Noradrenaline, Plasma
- Norepinephrine, Plasma
- Plasma Catecholamines
- Dopamine, Plasma
- Adrenalin, Plasma
- LAB963
Ordering Recommendations
Not recommended for evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma and paraganglioma, refer to Metanephrines, Plasma (Free) (0050184) or Metanephrines Fractionated by HPLC-MS/MS, Urine (2007996).
Result Interpretation |
Reference Interval
Supine
Components | Reference Interval | ||||
---|---|---|---|---|---|
Epinephrine |
| ||||
Norepinephrine |
| ||||
Dopamine | 2 days and older: 0-20 pg/mL |
Interpretive Data
Small increases in catecholamines (less than 2 times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (2 or more times the upper reference limit) is associated with an increased
probability of a neuroendocrine tumor. Measurement of plasma or urine fractionated metanephrines provides better diagnostic sensitivity than measurement of catecholamines.
Higher catecholamine concentrations are observed in specimens collected from upright or standing adults. Epinephrine may be increased by approximately 20 percent; norepinephrine up to 700 pg/mL; dopamine, unchanged.
probability of a neuroendocrine tumor. Measurement of plasma or urine fractionated metanephrines provides better diagnostic sensitivity than measurement of catecholamines.
Higher catecholamine concentrations are observed in specimens collected from upright or standing adults. Epinephrine may be increased by approximately 20 percent; norepinephrine up to 700 pg/mL; dopamine, unchanged.
Administrative |
CPT Codes
82384