Tests Catalogs

CARBAMAZEPINE EPOXIDE + TOTAL

LAB3012

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 6 days; Frozen: 1 month

Performed

Mon, Thu

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Enzyme Multiplied Immunoassay Technique

Reported

1-5 days

Synonyms

  • Tegretol, Metabolite
  • Tegretol
  • LAB3012
  • CARB EPOXT

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.

Reference Interval

Effective February 19, 2013
ComponentsTherapeutic Range
Carbamazepine-10, 11 EpoxideNot well established
Toxic:  Greater than 15.0 µg/mL
Total CarbamazepineTherapeutic Range: 4.0-12.0 µg/mL
Toxic:  Greater than 20.0 µg/mL

Interpretive Data

A proposed therapeutic range is 0.4-4 µg/mL. The metabolite, Carbamazepine-10, 11-Epoxide, has anticonvulsant activity to the parent drug.

CPT Codes

80156; 80299
Collection

LAB3012

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 6 days; Frozen: 1 month
Ordering

Performed

Mon, Thu

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Enzyme Multiplied Immunoassay Technique

Reported

1-5 days

Synonyms

  • Tegretol, Metabolite
  • Tegretol
  • LAB3012
  • CARB EPOXT

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.
Result Interpretation

Reference Interval

Effective February 19, 2013
ComponentsTherapeutic Range
Carbamazepine-10, 11 EpoxideNot well established
Toxic:  Greater than 15.0 µg/mL
Total CarbamazepineTherapeutic Range: 4.0-12.0 µg/mL
Toxic:  Greater than 20.0 µg/mL

Interpretive Data

A proposed therapeutic range is 0.4-4 µg/mL. The metabolite, Carbamazepine-10, 11-Epoxide, has anticonvulsant activity to the parent drug.

Administrative

CPT Codes

80156; 80299

CARBAMAZEPINE FREE & TOTAL

LAB22

Collect

Serum Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Unacceptable Conditions

Whole Blood, Citrated Plasma. Tubes that contain liquid anticoagulant.or Serum separator tube (SST).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 5 days; Refrigerated: 5 days; Frozen: 3 months

Remarks

Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.)

Performed

Mon, Wed, Fri

Methodology

Quantitative Enzyme Multiplied Immunoassay Technique

Reported

1-5 days

Synonyms

  • Free Tegretol
  • Tegretol, Free
  • Carbamazepine, Free
  • Free Carbamazepine
  • LAB22
  • CARB F/T

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.

Reference Interval

Effective November 16, 2015
Components
Reference Interval
Total CarbamazepineTherapeutic Range: 4.0-12.0 µg/mL
Toxic Range: Greater than 15 µg/mL
Free CarbamazepineTherapeutic Range: 1.0-3.0 µg/mL
Toxic Range: Greater than 3.8 µg/mL
Percent Free Carbamazepine8.0-35.0%

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Free carbamazepine may be important to monitor in patients with altered or unpredictable protein binding capacity. Carbamazepine is also subject to drug-drug interactions due to displacement of protein binding and extensive metabolism. Cross-reactivity with metabolites may account for differences in carbamazepine among analytical methods. Calculating percent free attempts to minimize differences in assay cross-reactivity and may be useful in dose optimization.  

CPT Codes

80156; 80157
Collection

LAB22

Collect

Serum Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Unacceptable Conditions

Whole Blood, Citrated Plasma. Tubes that contain liquid anticoagulant.or Serum separator tube (SST).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 5 days; Refrigerated: 5 days; Frozen: 3 months

Remarks

Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.)
Ordering

Performed

Mon, Wed, Fri

Methodology

Quantitative Enzyme Multiplied Immunoassay Technique

Reported

1-5 days

Synonyms

  • Free Tegretol
  • Tegretol, Free
  • Carbamazepine, Free
  • Free Carbamazepine
  • LAB22
  • CARB F/T

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.
Result Interpretation

Reference Interval

Effective November 16, 2015
Components
Reference Interval
Total CarbamazepineTherapeutic Range: 4.0-12.0 µg/mL
Toxic Range: Greater than 15 µg/mL
Free CarbamazepineTherapeutic Range: 1.0-3.0 µg/mL
Toxic Range: Greater than 3.8 µg/mL
Percent Free Carbamazepine8.0-35.0%

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Free carbamazepine may be important to monitor in patients with altered or unpredictable protein binding capacity. Carbamazepine is also subject to drug-drug interactions due to displacement of protein binding and extensive metabolism. Cross-reactivity with metabolites may account for differences in carbamazepine among analytical methods. Calculating percent free attempts to minimize differences in assay cross-reactivity and may be useful in dose optimization.  

Administrative

CPT Codes

80156; 80157

CARBOHYDRATE DEF TRANSFERRIN

LAB961

Collect

One 7ml red top or SST tube .

Unacceptable Conditions

Room Temp

Refrig >5 days

Storage/Transport Temperature

Internal: Deliver to lab immediatley
Offsite: 0.1 mL serum Aliquot 0.1 mL serum and send frozen

Refrigerated ok for < 5 days

Remarks

Testing done Monday, Wednesday, Friday

Performed by

Mayo Medical Laboratories

Performed

Mon, Thurs

Methodology

Affinity Chromotography/Mass Spectrometry (MS)

Reported

Same day

Synonyms

  • LAB961

Performed by

Mayo Medical Laboratories

CPT Codes

82373

Collection

LAB961

Collect

One 7ml red top or SST tube .

Unacceptable Conditions

Room Temp

Refrig >5 days

Storage/Transport Temperature

Internal: Deliver to lab immediatley
Offsite: 0.1 mL serum Aliquot 0.1 mL serum and send frozen

Refrigerated ok for < 5 days

Remarks

Testing done Monday, Wednesday, Friday

Performed by

Mayo Medical Laboratories

Ordering

Performed

Mon, Thurs

Methodology

Affinity Chromotography/Mass Spectrometry (MS)

Reported

Same day

Synonyms

  • LAB961
Result Interpretation

Performed by

Mayo Medical Laboratories

Administrative

CPT Codes

82373

CARBON DIOXIDE

LAB55

CO2

 

Collect

One 4.5 mL green top with gel (PST), (lithium heparin plasma).

Pediatric Collection

At least 0.5 mL blood in a microtainer, green top with gel, plasma (lithium heparin).

Unacceptable Conditions

Grossly hemolyzed sample; citrate anticoagulant; incorrect container; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Centrifuge within 30 minutes of collection. Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Before centrifugation: 1 hour

After centrifugation: Ambient, 1 day; Refrigerated, 3 days

Plasma/ aliquot: Ambient, 1 day; Refrigerated, 3 days; Frozen, 1 month.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Differential rate pH

Reported

Same day

Synonyms

  • LAB55
  • CO2

Reference Interval

Effective 05/20/2014:

21 - 31 mmol/L

 

Before 05/20/2014:

22-32 mmol/L

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82374

Collection

LAB55

CO2

 

Collect

One 4.5 mL green top with gel (PST), (lithium heparin plasma).

Pediatric Collection

At least 0.5 mL blood in a microtainer, green top with gel, plasma (lithium heparin).

Unacceptable Conditions

Grossly hemolyzed sample; citrate anticoagulant; incorrect container; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Centrifuge within 30 minutes of collection. Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Before centrifugation: 1 hour

After centrifugation: Ambient, 1 day; Refrigerated, 3 days

Plasma/ aliquot: Ambient, 1 day; Refrigerated, 3 days; Frozen, 1 month.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Differential rate pH

Reported

Same day

Synonyms

  • LAB55
  • CO2
Result Interpretation

Reference Interval

Effective 05/20/2014:

21 - 31 mmol/L

 

Before 05/20/2014:

22-32 mmol/L

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82374

CARBOXYHEMOGLOBIN

LAB56

CO HGB

Collect

At least 1.0 mL arterial or venous whole blood collected in a plastic blood gas syringe with dry balanced heparin anticoagulant. Immediately remove any syringe air bubbles from collected sample prior to transport. Remove needle prior to transportation.

 

Also acceptable: One 4.0 mL green top no gel ( Sodium heparin).

Pediatric Collection

Minimum volume: 0.5 mL blood.

Unacceptable Conditions

Clotted sample; syringe with needle attached; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Deliver to lab at ambient temperature.

Stability (from collection to initiation)

Stable for > 4 months in a filled well capped tube.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Co-oximetry (spectrophotometric)

Reported

Same day

Synonyms

  • CARBON MONOXIDE - CO
  • CO - CARBOXYHEMOGLOBIN
  • LAB56

Reference Interval

0-2 %

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82375

Collection

LAB56

CO HGB

Collect

At least 1.0 mL arterial or venous whole blood collected in a plastic blood gas syringe with dry balanced heparin anticoagulant. Immediately remove any syringe air bubbles from collected sample prior to transport. Remove needle prior to transportation.

 

Also acceptable: One 4.0 mL green top no gel ( Sodium heparin).

Pediatric Collection

Minimum volume: 0.5 mL blood.

Unacceptable Conditions

Clotted sample; syringe with needle attached; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Deliver to lab at ambient temperature.

Stability (from collection to initiation)

Stable for > 4 months in a filled well capped tube.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Co-oximetry (spectrophotometric)

Reported

Same day

Synonyms

  • CARBON MONOXIDE - CO
  • CO - CARBOXYHEMOGLOBIN
  • LAB56
Result Interpretation

Reference Interval

0-2 %

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82375

CARCINOEMBRYONIC ANTIGEN

LAB57

CEA C

Collect

One 5.0 mL gold or red top with gel (SST), (clot activator serum)

Pediatric Collection

Minimum volume: 1.5 mL blood.

Unacceptable Conditions

Sample not properly identified; insufficient sample volume; incorrect container.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Separate serum from cells. Refrigerate for up to 24 hours. Freeze up to 12 months.

Stability (from collection to initiation)

Separate serum from cells ASAP.

Refrigerated 24 hours; Frozen 12 months

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Chemillumenescent EIA

Reported

Daily

Synonyms

  • LAB57
  • CEA

Reference Interval

Nonsmoker 0.0-3.0 ng/mL

Smoker 0.0-5.0 ng/mL

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82378

Collection

LAB57

CEA C

Collect

One 5.0 mL gold or red top with gel (SST), (clot activator serum)

Pediatric Collection

Minimum volume: 1.5 mL blood.

Unacceptable Conditions

Sample not properly identified; insufficient sample volume; incorrect container.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Separate serum from cells. Refrigerate for up to 24 hours. Freeze up to 12 months.

Stability (from collection to initiation)

Separate serum from cells ASAP.

Refrigerated 24 hours; Frozen 12 months

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Chemillumenescent EIA

Reported

Daily

Synonyms

  • LAB57
  • CEA
Result Interpretation

Reference Interval

Nonsmoker 0.0-3.0 ng/mL

Smoker 0.0-5.0 ng/mL

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82378

CARCINOEMBRYONIC ANTIGEN BF

LAB3329

CEA BF

Collect

At least 0.3 mL body fluid in a sterile container.  No synovial fluid or other highly viscous fluids.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Spin and separate from cells if bloody. Transport refrigerated.

Stability (from collection to initiation)

Ambient: 8 hours; Refrigerated: 48 hours. Freeze for longer storage.

Performed by

PCL Clinical Laboratory - Core

Performed

Daily

Methodology

Chemillumenescent EIA

Reported

Daily

Synonyms

  • LAB3329
  • CEA BF

Interpretive Data

The reference range for carcinoembryonic antigen in body fluids is undefined.  The test result must be integrated into the clinical context for interpretation and/or compared to a synchronous serum or plasma measurement.  This test was developed and its performance characteristics determined by University of Colorado Hospital.  It has not been cleared or approved by the FDA.  The laboratory is regulated under CLIA as qualified to perform high-complexity testing.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82378

Collection

LAB3329

CEA BF

Collect

At least 0.3 mL body fluid in a sterile container.  No synovial fluid or other highly viscous fluids.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Spin and separate from cells if bloody. Transport refrigerated.

Stability (from collection to initiation)

Ambient: 8 hours; Refrigerated: 48 hours. Freeze for longer storage.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Daily

Methodology

Chemillumenescent EIA

Reported

Daily

Synonyms

  • LAB3329
  • CEA BF
Result Interpretation

Interpretive Data

The reference range for carcinoembryonic antigen in body fluids is undefined.  The test result must be integrated into the clinical context for interpretation and/or compared to a synchronous serum or plasma measurement.  This test was developed and its performance characteristics determined by University of Colorado Hospital.  It has not been cleared or approved by the FDA.  The laboratory is regulated under CLIA as qualified to perform high-complexity testing.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82378

CARNITINE FREE & TOTAL

LAB3211

Collect

Green (sodium or lithium heparin). Also acceptable: Plain red.

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.2 mL) Avoid hemolysis.

Unacceptable Conditions

Room temperature specimens. Specimens refrigerated greater than 12 hours.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 12 hours; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Notes

The concentration of esterified carnitine is derived from a mathematical calculation using free and total carnitine.

Performed

Tue-Sat

Methodology

Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • LAB3211
  • CARN F&T

Additional Technical Information

Ordering Recommendations

• Useful in the diagnosis of primary carnitine deficiency (carnitine uptake defect). • Monitor carnitine status.

Reference Interval

AgeFree CarnitineTotal CarnitineEsterified CarnitineRatio Esterified: Free
1 - 31 days15 - 55 µmol/L21 - 83 µmol/L4 - 29 µmol/L0.2 - 0.8
32 days-12 months29 - 61 µmol/L38 - 73 µmol/L7 - 24 µmol/L0.1 - 0.8
13 months - 6 years25 - 55 µmol/L35 - 90 µmol/L4 - 36 µmol/L0.1 - 0.8
7 years -20 years22 - 63 µmol/L31 - 78 µmol/L3 - 38 µmol/L0.1 - 0.9
21 years or older25 - 60 µmol/L34 - 86 µmol/L5 - 29 µmol/L0.1 - 1.0

CPT Codes

82379
Collection

LAB3211

Collect

Green (sodium or lithium heparin). Also acceptable: Plain red.

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.2 mL) Avoid hemolysis.

Unacceptable Conditions

Room temperature specimens. Specimens refrigerated greater than 12 hours.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 12 hours; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Notes

The concentration of esterified carnitine is derived from a mathematical calculation using free and total carnitine.
Ordering

Performed

Tue-Sat

Methodology

Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • LAB3211
  • CARN F&T

Additional Technical Information

Ordering Recommendations

• Useful in the diagnosis of primary carnitine deficiency (carnitine uptake defect). • Monitor carnitine status.
Result Interpretation

Reference Interval

AgeFree CarnitineTotal CarnitineEsterified CarnitineRatio Esterified: Free
1 - 31 days15 - 55 µmol/L21 - 83 µmol/L4 - 29 µmol/L0.2 - 0.8
32 days-12 months29 - 61 µmol/L38 - 73 µmol/L7 - 24 µmol/L0.1 - 0.8
13 months - 6 years25 - 55 µmol/L35 - 90 µmol/L4 - 36 µmol/L0.1 - 0.8
7 years -20 years22 - 63 µmol/L31 - 78 µmol/L3 - 38 µmol/L0.1 - 0.9
21 years or older25 - 60 µmol/L34 - 86 µmol/L5 - 29 µmol/L0.1 - 1.0

Administrative

CPT Codes

82379

CAROTENE, SERUM TOTAL

LAB702

Collect

Serum separator tube or plain red.

Patient Preparation

Fasting specimens preferred.

Specimen Preparation

Protect from light during collection, storage, and shipment. Separate serum from cells within 1 hour of collection. Transfer 2 mL serum to ARUP Amber Transport Tube. (Min: 0.6 mL)

Unacceptable Conditions

Any specimen other than serum. Refrigerated or room temperature specimens. Hemolyzed or icteric specimens.

Storage/Transport Temperature

Frozen. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 4 hours; Frozen: 1 month

Performed

Mon-Sat

Methodology

Quantitative Spectrophotometry

Reported

1-3 days

Synonyms

  • Carotene
  • LAB702

Ordering Recommendations

Use to assess fat malabsorption.

Reference Interval

60-200 µg/dL

CPT Codes

82380
Collection

LAB702

Collect

Serum separator tube or plain red.

Patient Preparation

Fasting specimens preferred.

Specimen Preparation

Protect from light during collection, storage, and shipment. Separate serum from cells within 1 hour of collection. Transfer 2 mL serum to ARUP Amber Transport Tube. (Min: 0.6 mL)

Unacceptable Conditions

Any specimen other than serum. Refrigerated or room temperature specimens. Hemolyzed or icteric specimens.

Storage/Transport Temperature

Frozen. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 4 hours; Frozen: 1 month
Ordering

Performed

Mon-Sat

Methodology

Quantitative Spectrophotometry

Reported

1-3 days

Synonyms

  • Carotene
  • LAB702

Ordering Recommendations

Use to assess fat malabsorption.
Result Interpretation

Reference Interval

60-200 µg/dL
Administrative

CPT Codes

82380

CATECHOLAMINES, URINE FREE

LAB373

Collect

24-hour or random urine. Refrigerate 24-hour specimen during collection.

Patient Preparation

Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible.

Specimen Preparation

Thoroughly mix entire collection (24-hour or Random) in one container. Transfer a 4 mL aliquot to an ARUP Standard Transport Tube. (Min: 2.5 mL) Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of 6M HCl acid or sulfamic acid prior to transport. A pH less than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
Option 1: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube. Adjust pH to 2.0-4.0 with 6M HCl.
Option 2: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™or contact ARUP Client Services at (800) 522-2787. (Min: 2.5 mL).

Unacceptable Conditions

Room temperature specimens. Specimens preserved with boric acid or acetic acid. Specimens with pH greater than 7.

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 1 week (unpreserved), 1 month (preserved); Frozen: 6 months (preserved)

Notes

Secreting neuroendocrine tumors are typically associated with catecholamine concentrations several times higher than the upper reference intervals. Large elevations can be seen in life-threatening illnesses and drug interferences. Common reasons for slight and moderate elevations include intense physical activity, emotional and physical stress, drug interferences, and improper specimen collection.

Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.

References: 1) Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. (Clinical Chemistry 1993; 39:2503-8.);  2) Effect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine. (Clinical Chemistry 1998; 44: 1759-62).

Performed

Sun-Sat

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • Norepinephrine, Random Urine
  • Fractionation, Urinary Free Catecholamines
  • Dopamine, Random Urine
  • Free Catecholamine Fractionation
  • Epinephrine, Random Urine
  • Adrenaline
  • Noradrenaline
  • LAB373
  • CATE UF

Ordering Recommendations

Not recommended for evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma and paraganglioma, refer to fractionated metanephrines in plasma (0050184) or urine (2007996).

Reference Interval

Reference Intervals for 24-Hour Calculations (24-Hour Urine)
Components
Reference Interval
Dopamine, Urine - per 24h
Effective August 17, 2015
Age
Dopamine
0-3 yearsNot Established
4-6 years95-221 µg/d
7-12 years76-371 µg/d
13-17 years137-393 µg/d
18-69 years77-324 µg/d
70 years and older56-272 µg/d

Epinephrine, Urine - per 24h
Effective August 17, 2015
AgeEpinephrine
0-3 yearsNot Established
4-17 years1-9 µg/d
18-69 years1-7 µg/d
70 years and older1-5 µg/d

Norepinephrine, Urine - per 24h
Effective August 17, 2015
AgeNorepinephrine
0-3 yearsNot Established
4-12 years6-45 µg/d
13-17 years15-57 µg/d
18-69 years16-71 µg/d
70 years and older11-60 µg/d

Creatinine, 24-Hour Urine
Age
Male
Female
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d


Reference Intervals for Ratio-to-Creatinine (CRT) Calculations (Random Urine)
Components
Reference Interval
AgeDopamine
Dopamine0-11 months
1-3 years
4-10 years
11-17 years
18 years and older		240-1290 µg/g crt
80-1220 µg/g crt
220-720 µg/g crt
120-450 µg/g crt
0-250 µg/g crt
AgeEpinephrine
Epinephrine0-11 months
1-3 years
4-10 years
11-17 years
18 years and older		0-380 µg/g crt
0-82 µ/g crt
5-93 µg/g crt
3-58 µg/g crt
0-20 µg/g crt
AgeNorepinephrine
Norepinephrine0-11 months
1-3 years
4 -10 years
11-17 years
18 years and older		25-310 µg/g crt
25-290 µg/g crt
27-110 µg/g crt
4-105 µg/g crt
0-45 µg/g crt

Interpretive Data

The optimal specimen for this testing is a 24-hour urine collection. Mass per day calculations are not reported for patients younger than 4 years of age and for the following specimen types: a random collection, a collection with duration of less than 20 hours, a collection with duration of greater than 28 hours, or a collection with total volume less than 400 mL (if 18 years of age or older) or greater than 5000 mL (all ages). Ratios to creatinine may be useful for these evaluations.

Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.

CPT Codes

82384
Collection

LAB373

Collect

24-hour or random urine. Refrigerate 24-hour specimen during collection.

Patient Preparation

Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible.

Specimen Preparation

Thoroughly mix entire collection (24-hour or Random) in one container. Transfer a 4 mL aliquot to an ARUP Standard Transport Tube. (Min: 2.5 mL) Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of 6M HCl acid or sulfamic acid prior to transport. A pH less than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
Option 1: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube. Adjust pH to 2.0-4.0 with 6M HCl.
Option 2: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™or contact ARUP Client Services at (800) 522-2787. (Min: 2.5 mL).

Unacceptable Conditions

Room temperature specimens. Specimens preserved with boric acid or acetic acid. Specimens with pH greater than 7.

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 1 week (unpreserved), 1 month (preserved); Frozen: 6 months (preserved)

Notes

Secreting neuroendocrine tumors are typically associated with catecholamine concentrations several times higher than the upper reference intervals. Large elevations can be seen in life-threatening illnesses and drug interferences. Common reasons for slight and moderate elevations include intense physical activity, emotional and physical stress, drug interferences, and improper specimen collection.

Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.

References: 1) Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. (Clinical Chemistry 1993; 39:2503-8.);  2) Effect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine. (Clinical Chemistry 1998; 44: 1759-62).
Ordering

Performed

Sun-Sat

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • Norepinephrine, Random Urine
  • Fractionation, Urinary Free Catecholamines
  • Dopamine, Random Urine
  • Free Catecholamine Fractionation
  • Epinephrine, Random Urine
  • Adrenaline
  • Noradrenaline
  • LAB373
  • CATE UF

Ordering Recommendations

Not recommended for evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma and paraganglioma, refer to fractionated metanephrines in plasma (0050184) or urine (2007996).
Result Interpretation

Reference Interval

Reference Intervals for 24-Hour Calculations (24-Hour Urine)
Components
Reference Interval
Dopamine, Urine - per 24h
Effective August 17, 2015
Age
Dopamine
0-3 yearsNot Established
4-6 years95-221 µg/d
7-12 years76-371 µg/d
13-17 years137-393 µg/d
18-69 years77-324 µg/d
70 years and older56-272 µg/d

Epinephrine, Urine - per 24h
Effective August 17, 2015
AgeEpinephrine
0-3 yearsNot Established
4-17 years1-9 µg/d
18-69 years1-7 µg/d
70 years and older1-5 µg/d

Norepinephrine, Urine - per 24h
Effective August 17, 2015
AgeNorepinephrine
0-3 yearsNot Established
4-12 years6-45 µg/d
13-17 years15-57 µg/d
18-69 years16-71 µg/d
70 years and older11-60 µg/d

Creatinine, 24-Hour Urine
Age
Male
Female
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d


Reference Intervals for Ratio-to-Creatinine (CRT) Calculations (Random Urine)
Components
Reference Interval
AgeDopamine
Dopamine0-11 months
1-3 years
4-10 years
11-17 years
18 years and older		240-1290 µg/g crt
80-1220 µg/g crt
220-720 µg/g crt
120-450 µg/g crt
0-250 µg/g crt
AgeEpinephrine
Epinephrine0-11 months
1-3 years
4-10 years
11-17 years
18 years and older		0-380 µg/g crt
0-82 µ/g crt
5-93 µg/g crt
3-58 µg/g crt
0-20 µg/g crt
AgeNorepinephrine
Norepinephrine0-11 months
1-3 years
4 -10 years
11-17 years
18 years and older		25-310 µg/g crt
25-290 µg/g crt
27-110 µg/g crt
4-105 µg/g crt
0-45 µg/g crt

Interpretive Data

The optimal specimen for this testing is a 24-hour urine collection. Mass per day calculations are not reported for patients younger than 4 years of age and for the following specimen types: a random collection, a collection with duration of less than 20 hours, a collection with duration of greater than 28 hours, or a collection with total volume less than 400 mL (if 18 years of age or older) or greater than 5000 mL (all ages). Ratios to creatinine may be useful for these evaluations.

Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.

Administrative

CPT Codes

82384

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