Tests Catalogs

COCCIDIOIDES AB BY COMP FIX

LAB3146

Collect

Serum separator tube OR CSF.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum OR CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."

Unacceptable Conditions

Contaminated or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing at least a fourfold rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.

Performed

Sun-Sat

Methodology

Semi-Quantitative Complement Fixation

Reported

1-3 days

Synonyms

  • Valley Fever by CF
  • San Joaquin Fever Antibody by CF
  • LAB3146

Ordering Recommendations

Titers may aid in monitoring coccidioidomycosis (Valley fever) and treatment response. For the initial establishment of diagnosis, refer to the preferred panel (0050588), which combines complement fixation and immunodiffusion.

Reference Interval

Less than 1:2

Interpretive Data

Any titer suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative Complement Fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; titers greater than or equal to 1:32 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.

CPT Codes

86635
Collection

LAB3146

Collect

Serum separator tube OR CSF.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum OR CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."

Unacceptable Conditions

Contaminated or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing at least a fourfold rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
Ordering

Performed

Sun-Sat

Methodology

Semi-Quantitative Complement Fixation

Reported

1-3 days

Synonyms

  • Valley Fever by CF
  • San Joaquin Fever Antibody by CF
  • LAB3146

Ordering Recommendations

Titers may aid in monitoring coccidioidomycosis (Valley fever) and treatment response. For the initial establishment of diagnosis, refer to the preferred panel (0050588), which combines complement fixation and immunodiffusion.
Result Interpretation

Reference Interval

Less than 1:2

Interpretive Data

Any titer suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative Complement Fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; titers greater than or equal to 1:32 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.

Administrative

CPT Codes

86635

COCCIDIOIDES ANTIBODY PANEL

LAB791

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer two 1 mL aliquots of serum to individual ARUP Standard Transport Tube. (Min: 0.3 mL per aliquot) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred.  Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.

Performed

Refer to individual components

Methodology

Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Reported

2-5 days

Synonyms

  • Valley Fever Antibodies
  • Valley Fever (Serum)
  • San Joaquin Fever Antibodies (Serum) CF, IgG, ELISA
  • LAB791

Ordering Recommendations

Preferred serology test for detecting coccidioidomycosis (Valley fever).

Reference Interval

Effective November 18, 2013
Components
Reference Interval
Coccidioides Antibody by CFLess than 1:2
Coccidioides immitis Antibodies by ImmunodiffusionNone detected.
Coccidioides Antibody, IgG by ELISA0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Coccidioides Antibody, IgM by ELISA0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

Refer to individual components.

CPT Codes

86635 x4
Collection

LAB791

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer two 1 mL aliquots of serum to individual ARUP Standard Transport Tube. (Min: 0.3 mL per aliquot) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred.  Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
Ordering

Performed

Refer to individual components

Methodology

Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Reported

2-5 days

Synonyms

  • Valley Fever Antibodies
  • Valley Fever (Serum)
  • San Joaquin Fever Antibodies (Serum) CF, IgG, ELISA
  • LAB791

Ordering Recommendations

Preferred serology test for detecting coccidioidomycosis (Valley fever).
Result Interpretation

Reference Interval

Effective November 18, 2013
Components
Reference Interval
Coccidioides Antibody by CFLess than 1:2
Coccidioides immitis Antibodies by ImmunodiffusionNone detected.
Coccidioides Antibody, IgG by ELISA0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Coccidioides Antibody, IgM by ELISA0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

Refer to individual components.

Administrative

CPT Codes

86635 x4

COLD AGGLUTININ TITER

LAB849

Collect

Serum separator tube or plain red.

Specimen Preparation

Keep in warm water (37°C) until processed for transport by laboratory; refrigeration of specimen before separation of serum from cells will adversely affect test results. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)

Unacceptable Conditions

Plasma or CSF. Refrigerated whole blood. Contaminated, severely hemolyzed, or lipemic, specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Performed

Tue, Thu, Sat

Methodology

Semi-Quantitative Hemagglutination

Reported

2-7 days

Synonyms

  • LAB849

Reference Interval

< 1:32 Negative

Interpretive Data

Titers of 1:32 or higher are considered elevated by this technique. Elevated titers are rarely seen except in primary atypical pneumonia and in certain hemolytic anemias. If the agglutination is not reversible after incubation at 37°C, then the reaction is not due to cold agglutinins.

Primary atypical pneumonia can be caused by Mycoplasma pneumoniae, influenza A, influenza B, parainfluenza, and adenoviruses. However, a fourfold rise in the cold agglutinins usually begins to appear late in the first week or during the second week of the disease and begins to decrease between the fourth and sixth weeks.  Low titers of cold agglutinins have been demonstrated in malaria, peripheral vascular disease, and common respiratory disease.

CPT Codes

86157
Collection

LAB849

Collect

Serum separator tube or plain red.

Specimen Preparation

Keep in warm water (37°C) until processed for transport by laboratory; refrigeration of specimen before separation of serum from cells will adversely affect test results. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)

Unacceptable Conditions

Plasma or CSF. Refrigerated whole blood. Contaminated, severely hemolyzed, or lipemic, specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Ordering

Performed

Tue, Thu, Sat

Methodology

Semi-Quantitative Hemagglutination

Reported

2-7 days

Synonyms

  • LAB849
Result Interpretation

Reference Interval

< 1:32 Negative

Interpretive Data

Titers of 1:32 or higher are considered elevated by this technique. Elevated titers are rarely seen except in primary atypical pneumonia and in certain hemolytic anemias. If the agglutination is not reversible after incubation at 37°C, then the reaction is not due to cold agglutinins.

Primary atypical pneumonia can be caused by Mycoplasma pneumoniae, influenza A, influenza B, parainfluenza, and adenoviruses. However, a fourfold rise in the cold agglutinins usually begins to appear late in the first week or during the second week of the disease and begins to decrease between the fourth and sixth weeks.  Low titers of cold agglutinins have been demonstrated in malaria, peripheral vascular disease, and common respiratory disease.

Administrative

CPT Codes

86157

COMPLEMENT 2

LAB153

Collect

Serum separator tube.

Specimen Preparation

Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.3 mL)

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Specimens left to clot at refrigerated temperature.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks

Performed

Mon, Thu

Methodology

Quantitative Radial Immunodiffusion

Reported

5-10 days

Synonyms

  • C2
  • LAB153

Ordering Recommendations

Follow-up test for complement activity screening when CH50 is low or absent and AH50 is normal and high suspicion remains for complement deficiency.

Reference Interval

1.0-4.0 mg/dL

Interpretive Data

Decreased C2 levels may be associated with increased susceptibility to infection (especially pneumococcal infections), systemic lupus erythematosus-like disease, rashes, arthritis, nephritis, and with C1-Esterase deficiency.  Increased C2 levels are associated with the acute phase response.

CPT Codes

86160
Collection

LAB153

Collect

Serum separator tube.

Specimen Preparation

Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.3 mL)

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Specimens left to clot at refrigerated temperature.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks
Ordering

Performed

Mon, Thu

Methodology

Quantitative Radial Immunodiffusion

Reported

5-10 days

Synonyms

  • C2
  • LAB153

Ordering Recommendations

Follow-up test for complement activity screening when CH50 is low or absent and AH50 is normal and high suspicion remains for complement deficiency.
Result Interpretation

Reference Interval

1.0-4.0 mg/dL

Interpretive Data

Decreased C2 levels may be associated with increased susceptibility to infection (especially pneumococcal infections), systemic lupus erythematosus-like disease, rashes, arthritis, nephritis, and with C1-Esterase deficiency.  Increased C2 levels are associated with the acute phase response.

Administrative

CPT Codes

86160

COMPLEMENT COMPONENT C5

LAB3141

Collect

Serum separator tube.

Specimen Preparation

Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.3 mL)

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Specimens left to clot at refrigerated temperature.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks

Performed

Tue, Fri

Methodology

Quantitative Radial Immunodiffusion

Reported

3-8 days

Synonyms

  • C5
  • LAB3141

Ordering Recommendations

Follow-up test for complement activity screening when CH50 and AH50 are low or absent and high suspicion remains for complement deficiency.

Reference Interval

7-20 mg/dL

CPT Codes

86160
Collection

LAB3141

Collect

Serum separator tube.

Specimen Preparation

Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.3 mL)

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Specimens left to clot at refrigerated temperature.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks
Ordering

Performed

Tue, Fri

Methodology

Quantitative Radial Immunodiffusion

Reported

3-8 days

Synonyms

  • C5
  • LAB3141

Ordering Recommendations

Follow-up test for complement activity screening when CH50 and AH50 are low or absent and high suspicion remains for complement deficiency.
Result Interpretation

Reference Interval

7-20 mg/dL
Administrative

CPT Codes

86160

COMPREHENSIVE FOOD PROFILE IGE - ALLERGENS

LAB8704

Collect

Serum separator tube. Multiple specimen tubes should be avoided.

Patient Preparation

Multiple patient encounters should be avoided.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.75 mL serum to an ARUP Standard Transport Tube. (Min: 1.24 mL)

Unacceptable Conditions

Hemolyzed, icteric, or lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Notes

Suggest ordering Food Profile, Common Adult

Performed

Sun-Sat

Methodology

Quantitative ImmunoCAP Fluorescent Enzyme Immunoassay

Reported

1-2 days

Synonyms

  • ALLERGENS - FOOD PROFILE
  • FOOD ALLERGEN PROFILE IGE
  • LAB8704

Reference Interval

Allergens included: Barley, Beef, Bell Pepper, Cabbage, Carrot, Chicken, Codfish/Whitefish, Corn, Crab, Egg White, Grape, Lettuce, Milk (Cow's), Navy Bean, Oat, Orange, Peanut, Pork, Potato, Rice, Rye, Shrimp, Soybean, Tomato, Tuna, Wheat.

Effective 02/18/2014
Reporting Range
(reported in kU/L)		Probability of IgE Mediated
Clinical Reaction		Class Scoring
Less than 0.10No significant level detected0
0.10 - 0.34Clinical relevance undetermined0/1
0.35 - 0.70Low1
0.71 - 3.50Moderate2
3.51 - 17.50High3
17.51 - 50.00Very high4
50.01 - 100.00Very high5
Greater than 100.00Very high6

Interpretive Data

Allergen results of 0.10-0.34 kU/L are intended for specialist use as the clinical relevance is undetermined. Even though increasing ranges are reflective of increasing concentrations of allergen-specific IgE, these concentrations may not correlate with the degree of clinical response or skin testing results when challenged with a specific allergen. The correlation of allergy laboratory results with clinical history and in vivo reactivity to specific allergens is essential. A negative test may not rule out clinical allergy or even anaphylaxis.

CPT Codes

86003 x26
Collection

LAB8704

Collect

Serum separator tube. Multiple specimen tubes should be avoided.

Patient Preparation

Multiple patient encounters should be avoided.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.75 mL serum to an ARUP Standard Transport Tube. (Min: 1.24 mL)

Unacceptable Conditions

Hemolyzed, icteric, or lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Notes

Suggest ordering Food Profile, Common Adult
Ordering

Performed

Sun-Sat

Methodology

Quantitative ImmunoCAP Fluorescent Enzyme Immunoassay

Reported

1-2 days

Synonyms

  • ALLERGENS - FOOD PROFILE
  • FOOD ALLERGEN PROFILE IGE
  • LAB8704
Result Interpretation

Reference Interval

Allergens included: Barley, Beef, Bell Pepper, Cabbage, Carrot, Chicken, Codfish/Whitefish, Corn, Crab, Egg White, Grape, Lettuce, Milk (Cow's), Navy Bean, Oat, Orange, Peanut, Pork, Potato, Rice, Rye, Shrimp, Soybean, Tomato, Tuna, Wheat.

Effective 02/18/2014
Reporting Range
(reported in kU/L)		Probability of IgE Mediated
Clinical Reaction		Class Scoring
Less than 0.10No significant level detected0
0.10 - 0.34Clinical relevance undetermined0/1
0.35 - 0.70Low1
0.71 - 3.50Moderate2
3.51 - 17.50High3
17.51 - 50.00Very high4
50.01 - 100.00Very high5
Greater than 100.00Very high6

Interpretive Data

Allergen results of 0.10-0.34 kU/L are intended for specialist use as the clinical relevance is undetermined. Even though increasing ranges are reflective of increasing concentrations of allergen-specific IgE, these concentrations may not correlate with the degree of clinical response or skin testing results when challenged with a specific allergen. The correlation of allergy laboratory results with clinical history and in vivo reactivity to specific allergens is essential. A negative test may not rule out clinical allergy or even anaphylaxis.

Administrative

CPT Codes

86003 x26

COMPREHENSIVE METABOLIC PANEL

LAB17

CMP

Collect

One 4.5 mL Green top with gel (PST), (lithium heparin plasma).

Pediatric Collection

At least 0.5 mL whole blood collected in microtainers, green top with gel, lithium heparin plasma.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Centrifuge within 2 hours of collection. Transport to laboratory at 2-8 degrees C.

Stability (from collection to initiation)

Before centrifugation: Ambient, 2 hours; Refrigerated, 2 hours. 

After centrifugation: Ambient, 8 hours; Refrigerated, 48 hours; Frozen (plasma aliquot, -20 degrees C), indefinitely - only one freeze/thaw cycle.

Performed by

PCL Clinical Laboratory - Core

Notes

For laboratories to bill Medicare, each component of a panel must be medically necessary for the treatment or diagnosis of the patient. All tests listed may be ordered individually.

Performed

Upon receipt

Methodology

Refer to individual components for methodology. Panel includes: Na, K, Cl, CO2, Glucose, Bun, Creatinine, Albumin, ALP, AST, ALT, Total Bilirubin, Calcium, Total Protein.

Reported

Same day

Synonyms

  • LAB17
  • CMP

Reference Interval

 Effective 05/20/2014:

Component Normal Low Normal High Units
ALANINE AMINOTRANSFERASE 7 52 U/L
ALBUMIN Age 0 minute - 1 month 2.8 4.2 g/dL
ALBUMIN Age 1 month - 150 yrs 3.5 5.7 g/dL
ALK PHOS, SERUM/PLASMA 39 117 U/L
ASPARTATE AMINOTRANSFERASE 12 39 U/L
BILIRUBIN TOTAL 0.1 1.3 mg/dL
BLOOD UREA NITROGEN 7 25 mg/dL
CALCIUM, SERUM/PLASMA 8.6 10.3 mg/dL
CARBON DIOXIDE 21 31 mmol/L
CHLORIDE, SERUM/PLASMA 98 108 mmol/L
CREATININE, SERUM/PLASMA, Male 0.7 1.3 mg/dL
CREATININE, SERUM/PLASMA, Female 0.6 1.2 mg/dL
GLUCOSE, RANDOM, SERUM/PLASMA 70 199 mg/dL
POTASSIUM, SERUM/PLASMA 3.5 5.1 mmol/L
PROTEIN TOTAL, SERUM/PLASMA 6.4 8.9 g/dL
SODIUM,SERUM/PLASMA 133 145 mmol/L

 

Before 05/20/2014:

Component Sex From Age To Age Normal Low Normal High Units
ALANINE AMINOTRANSFERASE M/F 0 1M 0 54 U/L
  M/F 1M 15 1 30 U/L
  M/F 15 150 0 47 U/L
ALBUMIN M/F 0 1 3.0 5.0 g/dL
  M/F 1 150 3.4 5.0 g/dL
ALK PHOS, SERUM/PLASMA M/F 0 7 115 460 U/L
  M/F 7 9 115 345 U/L
  M 9 11 115 336 U/L
  F 9 11 115 437 U/L
  M 11 13 127 403 U/L
  F 11 13 92 336 U/L
  F 13 15 78 212 U/L
  M 13 15 79 446 U/L
  M 15 18 58 331 U/L
  F 15 18 35 124 U/L
  M/F 18 150 39 117 U/L
ASPARTATE AMINOTRANSFERASE M/F 0 1M 25 75 U/L
  M/F 1M 15 0 40 U/L
  M/F 15 150 0 47 U/L
BILIRUBIN TOTAL M/F 0 1M 0.0 12.0 mg/dL
  M/F 1M 150 0.0 1.3 mg/dL
BLOOD UREA NITROGEN M/F 0 15 5 25 mg/dL
  M/F 15 150 6 23 mg/dL
CALCIUM, SERUM/PLASMA M/F 0 150 8.5 10.3 mg/dL
CARBON DIOXIDE M/F 0 150 22 32 mmol/L
CHLORIDE, SERUM/PLASMA M/F 0 16 97 108 mmol/L
  M/F 16 150 101 111 mmol/L
CREATININE, SERUM/PLASMA M/F 0 1 0.0 0.7 mg/dL
  M/F 1 3 0.0 0.8 mg/dL
  M/F 3 7 0.0 0.9 mg/dL
  M/F 7 10 0.0 1.1 mg/dL
  M/F 10 12 0.0 1.4 mg/dL
  M/F 12 17 0.0 1.4 mg/dL
  M/F 17 150 0.4 1.2 mg/dL
GLUCOSE, RANDOM, SERUM/PLASMA M/F 0 150 60 199 mg/dL
POTASSIUM, SERUM/PLASMA M/F 0 1D 3.5 6.0 mmol/L
  M/F 1D 16 3.5 5.0 mmol/L
  M/F 16 150 3.3 5.0 mmol/L
PROTEIN TOTAL, SERUM/PLASMA M/F 0 1M 4.7 6.7 g/dL
  M/F 1M 150 6.4 8.3 g/dL
SODIUM,SERUM/PLASMA M/F 0 1M 135 145 mmol/L
  M/F 1M 150 133 145 mmol/L

Interpretive Data

Effective 05/20/2014:

Adult reference ranges, excluding Albumin.

Performed by

PCL Clinical Laboratory - Core

CPT Codes

80053

Collection

LAB17

CMP

Collect

One 4.5 mL Green top with gel (PST), (lithium heparin plasma).

Pediatric Collection

At least 0.5 mL whole blood collected in microtainers, green top with gel, lithium heparin plasma.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Centrifuge within 2 hours of collection. Transport to laboratory at 2-8 degrees C.

Stability (from collection to initiation)

Before centrifugation: Ambient, 2 hours; Refrigerated, 2 hours. 

After centrifugation: Ambient, 8 hours; Refrigerated, 48 hours; Frozen (plasma aliquot, -20 degrees C), indefinitely - only one freeze/thaw cycle.

Performed by

PCL Clinical Laboratory - Core

Notes

For laboratories to bill Medicare, each component of a panel must be medically necessary for the treatment or diagnosis of the patient. All tests listed may be ordered individually.

Ordering

Performed

Upon receipt

Methodology

Refer to individual components for methodology. Panel includes: Na, K, Cl, CO2, Glucose, Bun, Creatinine, Albumin, ALP, AST, ALT, Total Bilirubin, Calcium, Total Protein.

Reported

Same day

Synonyms

  • LAB17
  • CMP
Result Interpretation

Reference Interval

 Effective 05/20/2014:

Component Normal Low Normal High Units
ALANINE AMINOTRANSFERASE 7 52 U/L
ALBUMIN Age 0 minute - 1 month 2.8 4.2 g/dL
ALBUMIN Age 1 month - 150 yrs 3.5 5.7 g/dL
ALK PHOS, SERUM/PLASMA 39 117 U/L
ASPARTATE AMINOTRANSFERASE 12 39 U/L
BILIRUBIN TOTAL 0.1 1.3 mg/dL
BLOOD UREA NITROGEN 7 25 mg/dL
CALCIUM, SERUM/PLASMA 8.6 10.3 mg/dL
CARBON DIOXIDE 21 31 mmol/L
CHLORIDE, SERUM/PLASMA 98 108 mmol/L
CREATININE, SERUM/PLASMA, Male 0.7 1.3 mg/dL
CREATININE, SERUM/PLASMA, Female 0.6 1.2 mg/dL
GLUCOSE, RANDOM, SERUM/PLASMA 70 199 mg/dL
POTASSIUM, SERUM/PLASMA 3.5 5.1 mmol/L
PROTEIN TOTAL, SERUM/PLASMA 6.4 8.9 g/dL
SODIUM,SERUM/PLASMA 133 145 mmol/L

 

Before 05/20/2014:

Component Sex From Age To Age Normal Low Normal High Units
ALANINE AMINOTRANSFERASE M/F 0 1M 0 54 U/L
  M/F 1M 15 1 30 U/L
  M/F 15 150 0 47 U/L
ALBUMIN M/F 0 1 3.0 5.0 g/dL
  M/F 1 150 3.4 5.0 g/dL
ALK PHOS, SERUM/PLASMA M/F 0 7 115 460 U/L
  M/F 7 9 115 345 U/L
  M 9 11 115 336 U/L
  F 9 11 115 437 U/L
  M 11 13 127 403 U/L
  F 11 13 92 336 U/L
  F 13 15 78 212 U/L
  M 13 15 79 446 U/L
  M 15 18 58 331 U/L
  F 15 18 35 124 U/L
  M/F 18 150 39 117 U/L
ASPARTATE AMINOTRANSFERASE M/F 0 1M 25 75 U/L
  M/F 1M 15 0 40 U/L
  M/F 15 150 0 47 U/L
BILIRUBIN TOTAL M/F 0 1M 0.0 12.0 mg/dL
  M/F 1M 150 0.0 1.3 mg/dL
BLOOD UREA NITROGEN M/F 0 15 5 25 mg/dL
  M/F 15 150 6 23 mg/dL
CALCIUM, SERUM/PLASMA M/F 0 150 8.5 10.3 mg/dL
CARBON DIOXIDE M/F 0 150 22 32 mmol/L
CHLORIDE, SERUM/PLASMA M/F 0 16 97 108 mmol/L
  M/F 16 150 101 111 mmol/L
CREATININE, SERUM/PLASMA M/F 0 1 0.0 0.7 mg/dL
  M/F 1 3 0.0 0.8 mg/dL
  M/F 3 7 0.0 0.9 mg/dL
  M/F 7 10 0.0 1.1 mg/dL
  M/F 10 12 0.0 1.4 mg/dL
  M/F 12 17 0.0 1.4 mg/dL
  M/F 17 150 0.4 1.2 mg/dL
GLUCOSE, RANDOM, SERUM/PLASMA M/F 0 150 60 199 mg/dL
POTASSIUM, SERUM/PLASMA M/F 0 1D 3.5 6.0 mmol/L
  M/F 1D 16 3.5 5.0 mmol/L
  M/F 16 150 3.3 5.0 mmol/L
PROTEIN TOTAL, SERUM/PLASMA M/F 0 1M 4.7 6.7 g/dL
  M/F 1M 150 6.4 8.3 g/dL
SODIUM,SERUM/PLASMA M/F 0 1M 135 145 mmol/L
  M/F 1M 150 133 145 mmol/L

Interpretive Data

Effective 05/20/2014:

Adult reference ranges, excluding Albumin.

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

80053

CONFIRMATION - OPIATES URINE

LAB4711

Collect

Random urine.

Specimen Preparation

Transfer 0.5 mL with no additives or preservatives urine to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.

Storage/Transport Temperature

Room temperature.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years

Performed

Sun-Sat

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • Oxycodone Urine Screen
  • Oxymorphone Urine Screen

Ordering Recommendations

Preferred test to follow-up presumptive results. For general screening, Opiates, Urine Screen with Reflex to Quantitation (2005093) is preferred.

Reference Interval

Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Codeine20 ng/mL
Morphine20 ng/mL
6-acetylmorphine10 ng/mL
Hydrocodone20 ng/mL
Norhydrocodone20 ng/mL
Hydromorphone20 ng/mL
Oxycodone20 ng/mL
Noroxycodone20 ng/mL
Oxymorphone20 ng/mL
Noroxymorphone20 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff: 20 ng/mL except as specified below:
   6-acetylmorphine10 ng/mL

For medical purposes only; not valid for forensic use.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. All drug analytes covered are in the non-glucuronidated (free) forms. The concentration value must be greater than or equal to the cutoff to be reported as positive. A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory. 

CPT Codes

80361; 80365 (Alt code: G0480)
Collection

LAB4711

Collect

Random urine.

Specimen Preparation

Transfer 0.5 mL with no additives or preservatives urine to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.

Storage/Transport Temperature

Room temperature.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years
Ordering

Performed

Sun-Sat

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-4 days

Synonyms

  • Oxycodone Urine Screen
  • Oxymorphone Urine Screen

Ordering Recommendations

Preferred test to follow-up presumptive results. For general screening, Opiates, Urine Screen with Reflex to Quantitation (2005093) is preferred.
Result Interpretation

Reference Interval

Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Codeine20 ng/mL
Morphine20 ng/mL
6-acetylmorphine10 ng/mL
Hydrocodone20 ng/mL
Norhydrocodone20 ng/mL
Hydromorphone20 ng/mL
Oxycodone20 ng/mL
Noroxycodone20 ng/mL
Oxymorphone20 ng/mL
Noroxymorphone20 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff: 20 ng/mL except as specified below:
   6-acetylmorphine10 ng/mL

For medical purposes only; not valid for forensic use.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. All drug analytes covered are in the non-glucuronidated (free) forms. The concentration value must be greater than or equal to the cutoff to be reported as positive. A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory. 

Administrative

CPT Codes

80361; 80365 (Alt code: G0480)

Congestive Heart Failure BNP

LAB106

BNP

Collect

One 6.0 mL pink top, plasma (EDTA).

Pediatric Collection

At least 0.6 mL whole blood collected in a microtainer, pink top (EDTA plasma).

Unacceptable Conditions

Grossly hemolyzed sample; anticoagulants other than EDTA; whole blood received more than 24 hours after draw time; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Centriguge within 30 minutes of collection. Immediately place plasma in an aliquot container and transport to lab at 2-8 degreees C.

Stability (from collection to initiation)

Before centrifugation: Ambient, 24 hours.

After centrifugation: Ambient, 8 hours; Refrigerated, 24 hours; Frozen, Unacceptable.

Plasma aliquot: Ambient, 8 hours; Refrigerated, 24 hours; Frozen(-20 degrees C), Undefined. Thaw only once.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Chemiluminescent immunoassay

Reported

Same day

Synonyms

  • LAB106
  • NATRIURETIC PEPTIDE

Reference Interval

0-100 pg/mL

Performed by

PCL Clinical Laboratory - Core

CPT Codes

83880

Collection

LAB106

BNP

Collect

One 6.0 mL pink top, plasma (EDTA).

Pediatric Collection

At least 0.6 mL whole blood collected in a microtainer, pink top (EDTA plasma).

Unacceptable Conditions

Grossly hemolyzed sample; anticoagulants other than EDTA; whole blood received more than 24 hours after draw time; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Centriguge within 30 minutes of collection. Immediately place plasma in an aliquot container and transport to lab at 2-8 degreees C.

Stability (from collection to initiation)

Before centrifugation: Ambient, 24 hours.

After centrifugation: Ambient, 8 hours; Refrigerated, 24 hours; Frozen, Unacceptable.

Plasma aliquot: Ambient, 8 hours; Refrigerated, 24 hours; Frozen(-20 degrees C), Undefined. Thaw only once.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Chemiluminescent immunoassay

Reported

Same day

Synonyms

  • LAB106
  • NATRIURETIC PEPTIDE
Result Interpretation

Reference Interval

0-100 pg/mL

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

83880

COPPER - TIMED URINE

LAB380

Collect

24-hour or random urine collection. Specimen must be collected in a plastic container. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately if tested within 14 days of collection.

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Unacceptable Conditions

Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine. Specimens contaminated with blood or fecal material. Specimens transported in non-trace element-free transport tube (with the exception of the original device).

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Notes

Refer to Copper-Ceruloplasmin Index (Copper Free) (0025079) for Wilson disease screening test.

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Reported

1-3 days

Synonyms

  • Cu, Urine
  • LAB380
  • CU-URINE

Additional Technical Information

Ordering Recommendations

Useful in the assessment of overload. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.

Reference Interval

Components
Reference Interval
Copper, Urine - per volume0.2-8.0 µg/dL
Copper, Urine - per 24h3-50 µg/d
Creatinine, Urine - per 24h
AgeMaleFemale
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d

Copper, Urine - ratio to CRTNo reference interval (µg/g crt)

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 µg copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.

CPT Codes

82525
Collection

LAB380

Collect

24-hour or random urine collection. Specimen must be collected in a plastic container. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately if tested within 14 days of collection.

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Unacceptable Conditions

Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine. Specimens contaminated with blood or fecal material. Specimens transported in non-trace element-free transport tube (with the exception of the original device).

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Notes

Refer to Copper-Ceruloplasmin Index (Copper Free) (0025079) for Wilson disease screening test.
Ordering

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Reported

1-3 days

Synonyms

  • Cu, Urine
  • LAB380
  • CU-URINE

Additional Technical Information

Ordering Recommendations

Useful in the assessment of overload. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.
Result Interpretation

Reference Interval

Components
Reference Interval
Copper, Urine - per volume0.2-8.0 µg/dL
Copper, Urine - per 24h3-50 µg/d
Creatinine, Urine - per 24h
AgeMaleFemale
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d

Copper, Urine - ratio to CRTNo reference interval (µg/g crt)

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 µg copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.

Administrative

CPT Codes

82525

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