Tests Catalogs

CLORAZEPATE

LAB3147

Collect

Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Unacceptable Conditions

Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles)

Performed

Tue, Fri

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-5 days

Synonyms

  • Tranxene
  • LAB3147
  • CLORAZ

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.

Reference Interval

Effective November 16, 2015
Dose-Related Range:100-1500 ng/mL based on common dosage amounts
Toxic:Greater than 2500 ng/mL

Interpretive Data

Clorazepate is assayed as nordiazepam. Toxic concentrations may cause central nervous system depression.

CPT Codes

80346 (Alt code: G0480)
Collection

LAB3147

Collect

Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Unacceptable Conditions

Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles)
Ordering

Performed

Tue, Fri

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-5 days

Synonyms

  • Tranxene
  • LAB3147
  • CLORAZ

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.
Result Interpretation

Reference Interval

Effective November 16, 2015
Dose-Related Range:100-1500 ng/mL based on common dosage amounts
Toxic:Greater than 2500 ng/mL

Interpretive Data

Clorazepate is assayed as nordiazepam. Toxic concentrations may cause central nervous system depression.

Administrative

CPT Codes

80346 (Alt code: G0480)

CLOZAPINE AND METABOLITE QUANTITATIVE

LAB3145

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 5 weeks; Refrigerated: 2 months; Frozen: 2 months

Performed

Sun-Sat

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-3 days

Synonyms

  • Clozaril
  • LAB3145
  • CLOZMET

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.

Reference Interval

Therapeutic RangeNot well established
Toxic LevelTotal Clozapine and Metabolites: Greater than or equal to 1500 ng/mL

Interpretive Data

Therapeutic ranges are not well established. Clozapine is metabolized to norclozapine and clozapine-N-oxide. Clozapine concentrations between 100 and 700 ng/mL may correlate more with clinical response; however, non-responsiveness may also occur within this range. For refractory schizophrenia, clozapine concentrations greater than 350 ng/mL are suggested to achieve a therapeutic response.

Toxicity: Toxic ranges are not well established. Serum/plasma concentrations greater than or equal to 1500 ng/mL (clozapine, norclozapine and clozapine-N-oxide combined) may cause drug-induced agranulocytosis, Stevens-Johnson syndrome, seizures, hypotension, cardiovascular abnormalities, drowsiness, and death.

Therapeutic and toxic ranges are not well established in children.

CPT Codes

80159
Collection

LAB3145

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 5 weeks; Refrigerated: 2 months; Frozen: 2 months
Ordering

Performed

Sun-Sat

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-3 days

Synonyms

  • Clozaril
  • LAB3145
  • CLOZMET

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.
Result Interpretation

Reference Interval

Therapeutic RangeNot well established
Toxic LevelTotal Clozapine and Metabolites: Greater than or equal to 1500 ng/mL

Interpretive Data

Therapeutic ranges are not well established. Clozapine is metabolized to norclozapine and clozapine-N-oxide. Clozapine concentrations between 100 and 700 ng/mL may correlate more with clinical response; however, non-responsiveness may also occur within this range. For refractory schizophrenia, clozapine concentrations greater than 350 ng/mL are suggested to achieve a therapeutic response.

Toxicity: Toxic ranges are not well established. Serum/plasma concentrations greater than or equal to 1500 ng/mL (clozapine, norclozapine and clozapine-N-oxide combined) may cause drug-induced agranulocytosis, Stevens-Johnson syndrome, seizures, hypotension, cardiovascular abnormalities, drowsiness, and death.

Therapeutic and toxic ranges are not well established in children.

Administrative

CPT Codes

80159

CMV by PCR, samples other than blood

LAB3244

Collect

If submitting a Pink Top tube (EDTA) whole blood, refer to test code CMVPCRBLD.

All sample types submitted in a sterile container, including serum from red top tube.

Specimen source must be included on requisition.

 

Pediatric Collection

At least 0.5 mL of sample in a sterile container.

Unacceptable Conditions

Whole blood or plasma samples; non sterile or leaking containers; sample not properly identified; insufficient sample volume; contaminated specimen; clotted sample; samples containing fixatives.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Send at 2-8 degrees C if delivered within 72 hours. If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

 

Stability (from collection to initiation)

Ambient, 12 hours; Refrigerated, 72 hours; Frozen (-70 degrees C), 6 months.

Remarks

Quantitative results will be given for all urine samples. Qualitative results will be given for tissues, stools, swabs, or diluted samples.

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Performed

Mon - Fri

Methodology

DNA amplification by polymerase chain reaction (PCR) using a CMV-specific DNA probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3244

Interpretive Data

 

Qualitative testing:

TND = Target Not Detected (negative)

Positive = Virus Detected

Quantitative testing:

TND = Target Not Detected (negative)

POS<1000 = Positive. Virus detected below 1000 copies/mL

1001 - 1,000,000 copies/mL = Quantitative range

>1,000,000 copies/mL = Greater than maximum quantitative range

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

CPT Codes

87497 (quantitative); 87496 (qualitative)

Collection

LAB3244

Collect

If submitting a Pink Top tube (EDTA) whole blood, refer to test code CMVPCRBLD.

All sample types submitted in a sterile container, including serum from red top tube.

Specimen source must be included on requisition.

 

Pediatric Collection

At least 0.5 mL of sample in a sterile container.

Unacceptable Conditions

Whole blood or plasma samples; non sterile or leaking containers; sample not properly identified; insufficient sample volume; contaminated specimen; clotted sample; samples containing fixatives.

Storage/Transport Temperature

Internal: Deliver to lab immediately at ambient temperature.
Offsite: Send at 2-8 degrees C if delivered within 72 hours. If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

 

Stability (from collection to initiation)

Ambient, 12 hours; Refrigerated, 72 hours; Frozen (-70 degrees C), 6 months.

Remarks

Quantitative results will be given for all urine samples. Qualitative results will be given for tissues, stools, swabs, or diluted samples.

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Ordering

Performed

Mon - Fri

Methodology

DNA amplification by polymerase chain reaction (PCR) using a CMV-specific DNA probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3244
Result Interpretation

Interpretive Data

 

Qualitative testing:

TND = Target Not Detected (negative)

Positive = Virus Detected

Quantitative testing:

TND = Target Not Detected (negative)

POS<1000 = Positive. Virus detected below 1000 copies/mL

1001 - 1,000,000 copies/mL = Quantitative range

>1,000,000 copies/mL = Greater than maximum quantitative range

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Administrative

CPT Codes

87497 (quantitative); 87496 (qualitative)

CMV EXPANDED GENOTYPE

LAB3227
CMVGENO

Collect

One 5 mL purple top [EDTA] - whole blood with a quantitative value of > 2000 copies/mL.

Positive isolate/ or any previous positive with a quantitative value of >2000 copies/mL.

Pediatric Collection

Minimum 3 mL EDTA whole blood.

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; positive samples with quantitative values <2000 copies/ml; negative samples; samples in fixatives.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite:  Transport refrigerated or on ice. Transport same day. If delivery is not expected within 24 hours, freeze at -70 C and ship on dry ice.

Stability (from collection to initiation)

Refrigerated: 72 hours ; Frozen (-70 degrees C): 6 months.

Remarks

Test is performed upon specimen receipt. The turn around for results is approximately 2 weeks. Sample must have a verifiable quantitative value of >2000 copies/ml or a CMV QUANT PCR BLOOD (LAB3243) must first be performed.

Test includes resistance to the following drugs: Ganciclovir, Cidofovir, Foscarnet, Maribavir, and Cyclopropavir.

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Performed

Upon receipt

Methodology

DNA sequencing

Reported

In 14 days

Synonyms

  • LAB3227
  • CMVGENO
  • Cytomegalovirus Genotyping

Interpretive Data

By report

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

CPT Codes

87910

Collection

LAB3227
CMVGENO

Collect

One 5 mL purple top [EDTA] - whole blood with a quantitative value of > 2000 copies/mL.

Positive isolate/ or any previous positive with a quantitative value of >2000 copies/mL.

Pediatric Collection

Minimum 3 mL EDTA whole blood.

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; positive samples with quantitative values <2000 copies/ml; negative samples; samples in fixatives.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite:  Transport refrigerated or on ice. Transport same day. If delivery is not expected within 24 hours, freeze at -70 C and ship on dry ice.

Stability (from collection to initiation)

Refrigerated: 72 hours ; Frozen (-70 degrees C): 6 months.

Remarks

Test is performed upon specimen receipt. The turn around for results is approximately 2 weeks. Sample must have a verifiable quantitative value of >2000 copies/ml or a CMV QUANT PCR BLOOD (LAB3243) must first be performed.

Test includes resistance to the following drugs: Ganciclovir, Cidofovir, Foscarnet, Maribavir, and Cyclopropavir.

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Ordering

Performed

Upon receipt

Methodology

DNA sequencing

Reported

In 14 days

Synonyms

  • LAB3227
  • CMVGENO
  • Cytomegalovirus Genotyping
Result Interpretation

Interpretive Data

By report

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Administrative

CPT Codes

87910

COBALT SERUM/PLASMA

LAB3760

Collect

Royal blue (no additive) or Royal blue (EDTA)

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Specimen Preparation

Centrifuge; Do not allow serum to remain on cells. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Unacceptable Conditions

Separator tubes. Specimens that are not separated from the red cells, or clot, within 6 hours.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Stability (from collection to initiation)

If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.

Notes

Elevated results from noncertified trace element-free tubes may be due to contamination.  Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Reported

1-5 days

Synonyms

  • LAB3760
  • COBALT SP

Additional Technical Information

Ordering Recommendations

May be used in the assessment of occupational exposure or toxic ingestion. Preferred test for evaluating metal ion release from metal-on-metal joint arthroplasty.

Reference Interval

Less than or equal to 1.0 µg/L

Interpretive Data

Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.

CPT Codes

83018
Collection

LAB3760

Collect

Royal blue (no additive) or Royal blue (EDTA)

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Specimen Preparation

Centrifuge; Do not allow serum to remain on cells. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Unacceptable Conditions

Separator tubes. Specimens that are not separated from the red cells, or clot, within 6 hours.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Stability (from collection to initiation)

If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.

Notes

Elevated results from noncertified trace element-free tubes may be due to contamination.  Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).
Ordering

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Reported

1-5 days

Synonyms

  • LAB3760
  • COBALT SP

Additional Technical Information

Ordering Recommendations

May be used in the assessment of occupational exposure or toxic ingestion. Preferred test for evaluating metal ion release from metal-on-metal joint arthroplasty.
Result Interpretation

Reference Interval

Less than or equal to 1.0 µg/L

Interpretive Data

Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.

Administrative

CPT Codes

83018

COCAINE METABOLITE CONF GC/MS

Collect

Random urine.

Specimen Preparation

Transfer 3.5 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.

Storage/Transport Temperature

Room temperature.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years

Performed

Sun-Sat

Methodology

Quantitative Gas Chromatography-Mass Spectrometry

Reported

1-4 days

Synonyms

  • -796

Ordering Recommendations

Preferred test to follow-up presumptive results. For general screening, Cocaine Urine with Reflex to Quantitation (2012231) is preferred.

Reference Interval

Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Benzoylecgonine50 ng/mL

Interpretive Data

Methodology: Quantitative Gas Chromatography-Mass Spectrometry

Positive cutoff: 50 ng/mL 

For medical purposes only; not valid for forensic use.

The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

CPT Codes

80353 (Alt code: G0480)
Collection

Collect

Random urine.

Specimen Preparation

Transfer 3.5 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.

Storage/Transport Temperature

Room temperature.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years
Ordering

Performed

Sun-Sat

Methodology

Quantitative Gas Chromatography-Mass Spectrometry

Reported

1-4 days

Synonyms

  • -796

Ordering Recommendations

Preferred test to follow-up presumptive results. For general screening, Cocaine Urine with Reflex to Quantitation (2012231) is preferred.
Result Interpretation

Reference Interval

Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Benzoylecgonine50 ng/mL

Interpretive Data

Methodology: Quantitative Gas Chromatography-Mass Spectrometry

Positive cutoff: 50 ng/mL 

For medical purposes only; not valid for forensic use.

The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Administrative

CPT Codes

80353 (Alt code: G0480)

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