VARICELLA ZOSTER IGG ANTIBODY

LAB162

VZV IGG

 

Collect

One 4.5 mL gold or red top with gel (SST), clot activator serum.

Also acceptable: One 6.0 mL red top no gel, serum (clot activator).

Pediatric Collection

At least 1.0 mL blood collected in a 4.5 mL gold or red top with gel (SST), clot activator serum, or other serum tube.

Unacceptable Conditions

Plasma samples; grossly contaminated, hemolyzed, lipemic or icteric samples; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal: Allow to clot for 30 minutes, then deliver to lab at ambient temperature.
Offsite: Allow to clot for 30 minutes, immediately centrifuge, place at least 2 mL of serum in an aliquot container. If tested within 7 days of collection, transport at 2-8 degrees C. If tested more than 7 days after collection, transport frozen.

Stability (from collection to initiation)

Before centrifugation: 1 hour

After centrifugation: Ambient, 1 hour; Refrigerated, 1 hour

Serum aliquot: Ambient, 1 hour; Refrigerated, 7 days; Frozen (-20 deg C), 1 month

 

 

Remarks

Stat priority is available for some high-risk obstetric patients. Call the laboratory to arrange.

Performed by

PCL Clinical Laboratory - Special Chemistry

Performed

Mondays and Thursdays

Methodology

Chemiluminescent immunoassay (CLIA)

Reported

Same day

Synonyms

  • VZVIGG
  • LAB162

Interpretive Data

POSITIVE: Indicates immunity against VZV.

NEGATIVE: No detectable VZV antibody; does not rule out acute infection.

EQUIVOCAL: Unable to determine the immune status. Repeat testing on a new sample after two or more weeks.

Performed by

PCL Clinical Laboratory - Special Chemistry

CPT Codes

86787

Collection

LAB162

VZV IGG

 

Collect

One 4.5 mL gold or red top with gel (SST), clot activator serum.

Also acceptable: One 6.0 mL red top no gel, serum (clot activator).

Pediatric Collection

At least 1.0 mL blood collected in a 4.5 mL gold or red top with gel (SST), clot activator serum, or other serum tube.

Unacceptable Conditions

Plasma samples; grossly contaminated, hemolyzed, lipemic or icteric samples; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal: Allow to clot for 30 minutes, then deliver to lab at ambient temperature.
Offsite: Allow to clot for 30 minutes, immediately centrifuge, place at least 2 mL of serum in an aliquot container. If tested within 7 days of collection, transport at 2-8 degrees C. If tested more than 7 days after collection, transport frozen.

Stability (from collection to initiation)

Before centrifugation: 1 hour

After centrifugation: Ambient, 1 hour; Refrigerated, 1 hour

Serum aliquot: Ambient, 1 hour; Refrigerated, 7 days; Frozen (-20 deg C), 1 month

 

 

Remarks

Stat priority is available for some high-risk obstetric patients. Call the laboratory to arrange.

Performed by

PCL Clinical Laboratory - Special Chemistry

Ordering

Performed

Mondays and Thursdays

Methodology

Chemiluminescent immunoassay (CLIA)

Reported

Same day

Synonyms

  • VZVIGG
  • LAB162
Result Interpretation

Interpretive Data

POSITIVE: Indicates immunity against VZV.

NEGATIVE: No detectable VZV antibody; does not rule out acute infection.

EQUIVOCAL: Unable to determine the immune status. Repeat testing on a new sample after two or more weeks.

Performed by

PCL Clinical Laboratory - Special Chemistry

Administrative

CPT Codes

86787

VARICELLA-ZOSTER VIRUS PCR BLOOD

LAB3235
VZVPCRBLD

Collect

6.0 mL pink top, plasma (EDTA), filled to at least 80% capacity.

Specimen source must be identified on order or requisition.

Pediatric Collection

At least 0.5 mL whole blood collected in a 1.0 mL pink top microtainer (EDTA) or other blood tube with EDTA anticoagulant.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; contaminated specimen; clotted sample; tubes not filled to 80-100% capacity; improper storage conditions; no fixatives allowed; specimens other than whole blood EDTA.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Do not centrifuge.  If delivered within 72 hours, send at 2-8 degrees C.  If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

Stability (from collection to initiation)

Ambient: 12 hours; Refrigerated: 72 hours; Frozen (-70 deg C): 6 months

Remarks

Qualitative results will be given.

Performed by

PCL Clinical Laboratory - Molecular Diagnosis

Performed

Mon-Fri

Methodology

DNA amplification by polymerase chain reaction (PCR) using a VZV-specific DNA probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3235
  • VZVPCRBLD

Interpretive Data

Not Detected (negative)

Detected (positive)

Performed by

PCL Clinical Laboratory - Molecular Diagnosis

CPT Codes

87798

Collection

LAB3235
VZVPCRBLD

Collect

6.0 mL pink top, plasma (EDTA), filled to at least 80% capacity.

Specimen source must be identified on order or requisition.

Pediatric Collection

At least 0.5 mL whole blood collected in a 1.0 mL pink top microtainer (EDTA) or other blood tube with EDTA anticoagulant.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; contaminated specimen; clotted sample; tubes not filled to 80-100% capacity; improper storage conditions; no fixatives allowed; specimens other than whole blood EDTA.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Do not centrifuge.  If delivered within 72 hours, send at 2-8 degrees C.  If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

Stability (from collection to initiation)

Ambient: 12 hours; Refrigerated: 72 hours; Frozen (-70 deg C): 6 months

Remarks

Qualitative results will be given.

Performed by

PCL Clinical Laboratory - Molecular Diagnosis

Ordering

Performed

Mon-Fri

Methodology

DNA amplification by polymerase chain reaction (PCR) using a VZV-specific DNA probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3235
  • VZVPCRBLD
Result Interpretation

Interpretive Data

Not Detected (negative)

Detected (positive)

Performed by

PCL Clinical Laboratory - Molecular Diagnosis

Administrative

CPT Codes

87798

VARICELLA-ZOSTER VIRUS QUAL PCR

LAB3349
VZVPCR

 

Collect

All sample types, except blood. Submit in a sterile container.

Specimen source must be identified on order or requisition.

If submitting a Pink top tube (EDTA), refer to test code LAB3235 VARICELLA-ZOSTER VIRUS PCR BLOOD.

Pediatric Collection

0.5 mL

Unacceptable Conditions

Sample not properly identified; insufficient sample volume; contaminated specimen; clotted sample; gross hemolysis; non sterile or leaking containers; and samples containing fixatives.

For whole blood, refer to test code LAB3235 VARICELLA-ZOSTER VIRUS PCR BLOOD.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Send at 2-8 degrees C if delivery is less than 72 hours. If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

Stability (from collection to initiation)

Ambient:  1 hour;  Refrigerated: 72 hours;  Frozen (-70 degrees C): 6 months

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Performed

Monday - Friday

Methodology

DNA amplification by polymerase chain reaction (PCR) using a VZV- specific probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3349
  • VZVPCR

Interpretive Data

Not Detected (negative)

Detected (positive)

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

CPT Codes

87798

Collection

LAB3349
VZVPCR

 

Collect

All sample types, except blood. Submit in a sterile container.

Specimen source must be identified on order or requisition.

If submitting a Pink top tube (EDTA), refer to test code LAB3235 VARICELLA-ZOSTER VIRUS PCR BLOOD.

Pediatric Collection

0.5 mL

Unacceptable Conditions

Sample not properly identified; insufficient sample volume; contaminated specimen; clotted sample; gross hemolysis; non sterile or leaking containers; and samples containing fixatives.

For whole blood, refer to test code LAB3235 VARICELLA-ZOSTER VIRUS PCR BLOOD.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Send at 2-8 degrees C if delivery is less than 72 hours. If delivery is not expected within 72 hours, freeze at -70 degrees C and ship on dry ice.

Stability (from collection to initiation)

Ambient:  1 hour;  Refrigerated: 72 hours;  Frozen (-70 degrees C): 6 months

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Ordering

Performed

Monday - Friday

Methodology

DNA amplification by polymerase chain reaction (PCR) using a VZV- specific probe detected by real-time PCR.

Reported

24-48 hours

Synonyms

  • LAB3349
  • VZVPCR
Result Interpretation

Interpretive Data

Not Detected (negative)

Detected (positive)

Performed by

PCL Clinical Laboratory - Molecular Diagnostics

Administrative

CPT Codes

87798

VASC ENDOTHELIAL GROWTH FACTOR

LAB3193

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Unacceptable Conditions

Hemolyzed specimens.

Storage/Transport Temperature

CRITICAL FROZEN. Additional specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 4 hours; Refrigerated: 6 hours; Frozen: 6 months

Performed

Tue

Methodology

Quantitative Chemiluminescent Immunoassay

Reported

1-8 days

Synonyms

  • LAB3193
  • VEGF

Reference Interval

9-86 pg/mL

Interpretive Data

This assay is performed using the QuantiGlo® Chemiluminescent EIA kit. Values obtained with different assay methods or kits cannot be used interchangeably.

CPT Codes

82397
Collection

LAB3193

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Unacceptable Conditions

Hemolyzed specimens.

Storage/Transport Temperature

CRITICAL FROZEN. Additional specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 4 hours; Refrigerated: 6 hours; Frozen: 6 months
Ordering

Performed

Tue

Methodology

Quantitative Chemiluminescent Immunoassay

Reported

1-8 days

Synonyms

  • LAB3193
  • VEGF
Result Interpretation

Reference Interval

9-86 pg/mL

Interpretive Data

This assay is performed using the QuantiGlo® Chemiluminescent EIA kit. Values obtained with different assay methods or kits cannot be used interchangeably.

Administrative

CPT Codes

82397

VASOACTIVE INTESTINAL POLYPEP

LAB1107

Collect

Protease Inhibitor tube (PPACK; Phe-Pro-Arg-cholormethylketone).

Specimen Preparation

Protease Inhibitor tube (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. A winged collection set must be used. NOT RECOMMENDED: Filling collection tubes directly through a needle/tube-holder assembly increases the risk of chemical reflux back into the vein of the patient. WARNING: Collection tubes are NOT STERILE. Mix Collection tube thoroughly. Separate the plasma from cells within 1 hour of collection by centrifugation. Transfer 1 mL plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.5 mL) Do not submit the collection tube for testing.

Unacceptable Conditions

Grossly hemolyzed specimens.

Storage/Transport Temperature

Requires Special Handling: Special collection kit must be obtained from PCL Clinical Lab. Call 720-848-4401 to obtain kit.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 3 months

Performed by

PCL Clinical Laboratory

Performed

Wed, Sat

Methodology

Quantitative Radioimmunoassay

Reported

3-7 days

Synonyms

  • LAB1107

Ordering Recommendations

Aids in the diagnosis of VIPoma.

Reference Interval

0-60 pg/mL

Performed by

PCL Clinical Laboratory

CPT Codes

84586
Collection

LAB1107

Collect

Protease Inhibitor tube (PPACK; Phe-Pro-Arg-cholormethylketone).

Specimen Preparation

Protease Inhibitor tube (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. A winged collection set must be used. NOT RECOMMENDED: Filling collection tubes directly through a needle/tube-holder assembly increases the risk of chemical reflux back into the vein of the patient. WARNING: Collection tubes are NOT STERILE. Mix Collection tube thoroughly. Separate the plasma from cells within 1 hour of collection by centrifugation. Transfer 1 mL plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.5 mL) Do not submit the collection tube for testing.

Unacceptable Conditions

Grossly hemolyzed specimens.

Storage/Transport Temperature

Requires Special Handling: Special collection kit must be obtained from PCL Clinical Lab. Call 720-848-4401 to obtain kit.

Stability (from collection to initiation)

After separation from cells: Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 3 months

Performed by

PCL Clinical Laboratory

Ordering

Performed

Wed, Sat

Methodology

Quantitative Radioimmunoassay

Reported

3-7 days

Synonyms

  • LAB1107

Ordering Recommendations

Aids in the diagnosis of VIPoma.
Result Interpretation

Reference Interval

0-60 pg/mL

Performed by

PCL Clinical Laboratory

Administrative

CPT Codes

84586

VASOPRESSIN/ADH

LAB3190

 

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells ASAP or within 2 hours of collection. Transfer 6 mL plasma to ARUP Standard Transport Tubes and freeze immediately. (Min: 2.5 mL)

Unacceptable Conditions

Non-frozen specimens.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 1 month

Performed

Mon, Wed, Fri

Methodology

Quantitative Radioimmunoassay

Reported

3-11 days

Synonyms

  • AVP Assay
  • Antidiuretic Hormone, Plasma
  • AVH, Plasma
  • ADH, Plasma
  • Vasopressin
  • LAB3190

Reference Interval

Effective May 21, 2012
0.0-6.9 pg/mL

CPT Codes

84588
Collection

LAB3190

 

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells ASAP or within 2 hours of collection. Transfer 6 mL plasma to ARUP Standard Transport Tubes and freeze immediately. (Min: 2.5 mL)

Unacceptable Conditions

Non-frozen specimens.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Stability (from collection to initiation)

After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 1 month
Ordering

Performed

Mon, Wed, Fri

Methodology

Quantitative Radioimmunoassay

Reported

3-11 days

Synonyms

  • AVP Assay
  • Antidiuretic Hormone, Plasma
  • AVH, Plasma
  • ADH, Plasma
  • Vasopressin
  • LAB3190
Result Interpretation

Reference Interval

Effective May 21, 2012
0.0-6.9 pg/mL
Administrative

CPT Codes

84588

VDRL CSF WITH REFLEX TITER

LAB207

Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Unacceptable Conditions

Plasma, serum, or other body fluids.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

If VDRL is weakly reactive or reactive, then a titer will be added. Additional charges apply.

Performed

Sun-Sat

Methodology

Semi-Quantitative Flocculation

Reported

1-2 days

Synonyms

  • VDRL Cerebrospinal Fluid with Reflex to Titer
  • LAB207

Ordering Recommendations

Preferred diagnostic assay for CSF specimens in suspected neurosyphilis.

Reference Interval

Nonreactive

CPT Codes

86592; if reflexed, add 86593
Collection

LAB207

Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Unacceptable Conditions

Plasma, serum, or other body fluids.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

If VDRL is weakly reactive or reactive, then a titer will be added. Additional charges apply.
Ordering

Performed

Sun-Sat

Methodology

Semi-Quantitative Flocculation

Reported

1-2 days

Synonyms

  • VDRL Cerebrospinal Fluid with Reflex to Titer
  • LAB207

Ordering Recommendations

Preferred diagnostic assay for CSF specimens in suspected neurosyphilis.
Result Interpretation

Reference Interval

Nonreactive
Administrative

CPT Codes

86592; if reflexed, add 86593

VENOUS BLOOD GAS

LAB79

VBG

Collect

At least 1.0 venous whole blood collected in a plastic blood gas syringe with dry balanced heparin anticoagulant.

Pediatric Collection

0.3 mL venous whole blood in tuberculin blood gas syringe with balanced heparin.

Unacceptable Conditions

Sample submitted with needle attached (remove immediately post collection); uncapped sample syringe; air bubbles in sample; clotted sample; EDTA or citrate anticoagulant; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal:Deliver to the laboratory immediately. Maintain sample at ambient temperature. Deliver to the laboratory within 30 minutes of collection. If sample cannot be submitted to the laboratory within 30 minutes, transport on cold pack.

Offsite: Utilize emergency courier to provide for transport criteria listed above.

Stability (from collection to initiation)

Ambient: 30 minutes;On Ice: 1 hour.

Remarks

Use of dry, balanced heparin improves electrolyte and pH accuracy. Immediately remove any air bubbles from collected sample prior to transport.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Ion Selective Electrode

Reported

Within 1 hour of receipt

Synonyms

  • LAB79
  • VBG

Reference Interval

LOW HIGH UNITS
PH VENOUS 7.330 7.430 units
PCO2 VENOUS 36 48 mmHg
TOTAL CO2 22 26 mmol/L

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82805

Collection

LAB79

VBG

Collect

At least 1.0 venous whole blood collected in a plastic blood gas syringe with dry balanced heparin anticoagulant.

Pediatric Collection

0.3 mL venous whole blood in tuberculin blood gas syringe with balanced heparin.

Unacceptable Conditions

Sample submitted with needle attached (remove immediately post collection); uncapped sample syringe; air bubbles in sample; clotted sample; EDTA or citrate anticoagulant; sample not properly identified; insufficient sample volume.

Storage/Transport Temperature

Internal:Deliver to the laboratory immediately. Maintain sample at ambient temperature. Deliver to the laboratory within 30 minutes of collection. If sample cannot be submitted to the laboratory within 30 minutes, transport on cold pack.

Offsite: Utilize emergency courier to provide for transport criteria listed above.

Stability (from collection to initiation)

Ambient: 30 minutes;On Ice: 1 hour.

Remarks

Use of dry, balanced heparin improves electrolyte and pH accuracy. Immediately remove any air bubbles from collected sample prior to transport.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Ion Selective Electrode

Reported

Within 1 hour of receipt

Synonyms

  • LAB79
  • VBG
Result Interpretation

Reference Interval

LOW HIGH UNITS
PH VENOUS 7.330 7.430 units
PCO2 VENOUS 36 48 mmHg
TOTAL CO2 22 26 mmol/L

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82805

VENOUS BLOOD GAS CORD

LAB77

VBG CORD

Collect

Plastic Arterial blood gas syringe with dry balanced heparin anticoagulant. or plastic arterial blood gas syringe coated with alternate heparin source.

Pediatric Collection

1.0 mL in standard blood gas syringe, or 0.3 mL in tuberculin blood gas syringe

Unacceptable Conditions

Samples not properly identified, incorrect container; insufficient sample volume. Sample submitted with needle attached (remove immediately post collection); Air bubbles in sample, clotted sample.

Storage/Transport Temperature

Internal:Transport at ambient temperature If sample cannot be submitted to the laboratory within 30 minutes, transport on ICE.

Offsite: If sample cannot be submitted to the laboratory within 30 minutes, transport on ICE via emergency courier.

Stability (from collection to initiation)

Ambient: 30 minutes;On Ice: 1 hour.

Remarks

Samples not properly identified, incorrect container; insufficient sample volume; sample submitted with needle attached (remove immediately post collection); Uncapped sample syringe, air bubbles in sample; clotted sample. Samples containing EDTA or Citrate.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon Receipt

Methodology

Ion Selective Electrode

Reported

Within 1 hour of receipt.

Synonyms

  • LAB77
  • VBG CORD

Performed by

PCL Clinical Laboratory - Core

CPT Codes

82805

Collection

LAB77

VBG CORD

Collect

Plastic Arterial blood gas syringe with dry balanced heparin anticoagulant. or plastic arterial blood gas syringe coated with alternate heparin source.

Pediatric Collection

1.0 mL in standard blood gas syringe, or 0.3 mL in tuberculin blood gas syringe

Unacceptable Conditions

Samples not properly identified, incorrect container; insufficient sample volume. Sample submitted with needle attached (remove immediately post collection); Air bubbles in sample, clotted sample.

Storage/Transport Temperature

Internal:Transport at ambient temperature If sample cannot be submitted to the laboratory within 30 minutes, transport on ICE.

Offsite: If sample cannot be submitted to the laboratory within 30 minutes, transport on ICE via emergency courier.

Stability (from collection to initiation)

Ambient: 30 minutes;On Ice: 1 hour.

Remarks

Samples not properly identified, incorrect container; insufficient sample volume; sample submitted with needle attached (remove immediately post collection); Uncapped sample syringe, air bubbles in sample; clotted sample. Samples containing EDTA or Citrate.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon Receipt

Methodology

Ion Selective Electrode

Reported

Within 1 hour of receipt.

Synonyms

  • LAB77
  • VBG CORD
Result Interpretation

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

82805

VerifyNOW - ADP Reactivity

LAB5525

Collect

Two 2.0 mL blue top Greiner High Altitude BioOne Vacuette blood collection tubes using a 21 gauge needle or larger.  Fill tubes only to fill line on the label. These tubes are specially designed for this test and cannot be substituted. Order tubes in Lawson, #191357.  Lab has limited supplies and may be able to provide in an emergency.

DO NOT CENTRIFUGE. DO NOT SEND IN THE PNEUMATIC TUBE SYSTEM.

Specimen Preparation

Store at room temperature. Do not agitate samples.

Unacceptable Conditions

Sample not properly identified; incorrect containers; insufficient sample volume; tube over- or under-filled; more than 4 hours since collection; agitated sample; refrigerated or frozen samples.

Storage/Transport Temperature

Internal: Deliver to lab immediately at room temperature. Do not use pneumatic tube system or agitate tubes during delivery.

Offsite: Submission of samples from outside facilities is strongly discouraged due to high risk of sample agitation and platelet activation. See Remarks.

Stability (from collection to initiation)

Ambient temperature:  3 hours*

Remarks

*Deliver to lab as soon as possible after sample collection.  Although samples are stable for 4 hours at room temperature, allow 1 hour for lab processing and testing by sending samples to the lab no later than 3 hours after sample collection.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Performed

Daily 07:00 - 20:00

Methodology

Turbidimetric-based optical detection.

Reported

Same day

Synonyms

  • PLAVIX
  • P2Y12
  • ADP REACT

Reference Interval

194 - 418 PRU

Interpretive Data

The test results are expressed in P2Y12 Reaction Units (PRU). PRU are arbitrary units derived by the test's manufacturer and indicate the extent of ADP-induced platelet clumping of fibrinogen-coated beads in the presence of PGE1.  PRU results may not exactly reflect findings obtained with classic ADP-induced platelet aggregation. PRU are thought to provide a measure of platelet activation mediated by the platelet P2Y12 (or ADP) receptor.  The reference range for individuals not taking drugs known to interact with this receptor is 194 - 418 PRU.  The precise significance of results above or below this range is not known.

This test may be abnormal if the patient has been treated with a Glycoprotein IIb/IIIa inhibitor within the preceding two weeks.  The manufacturer has reported no interference for patients with the following parameters:  Hematocrit values between 33 and 52%, platelet counts between 119 and 502 10 9/L, triglyceride concenterations of 41 - 824 mg/dL, cholesterol concentrations of 98 - 316 mg/dL, and fibrinogen levels between 171 and 599 mg/dL.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

CPT Codes

85576

Collection

LAB5525

Collect

Two 2.0 mL blue top Greiner High Altitude BioOne Vacuette blood collection tubes using a 21 gauge needle or larger.  Fill tubes only to fill line on the label. These tubes are specially designed for this test and cannot be substituted. Order tubes in Lawson, #191357.  Lab has limited supplies and may be able to provide in an emergency.

DO NOT CENTRIFUGE. DO NOT SEND IN THE PNEUMATIC TUBE SYSTEM.

Specimen Preparation

Store at room temperature. Do not agitate samples.

Unacceptable Conditions

Sample not properly identified; incorrect containers; insufficient sample volume; tube over- or under-filled; more than 4 hours since collection; agitated sample; refrigerated or frozen samples.

Storage/Transport Temperature

Internal: Deliver to lab immediately at room temperature. Do not use pneumatic tube system or agitate tubes during delivery.

Offsite: Submission of samples from outside facilities is strongly discouraged due to high risk of sample agitation and platelet activation. See Remarks.

Stability (from collection to initiation)

Ambient temperature:  3 hours*

Remarks

*Deliver to lab as soon as possible after sample collection.  Although samples are stable for 4 hours at room temperature, allow 1 hour for lab processing and testing by sending samples to the lab no later than 3 hours after sample collection.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Ordering

Performed

Daily 07:00 - 20:00

Methodology

Turbidimetric-based optical detection.

Reported

Same day

Synonyms

  • PLAVIX
  • P2Y12
  • ADP REACT
Result Interpretation

Reference Interval

194 - 418 PRU

Interpretive Data

The test results are expressed in P2Y12 Reaction Units (PRU). PRU are arbitrary units derived by the test's manufacturer and indicate the extent of ADP-induced platelet clumping of fibrinogen-coated beads in the presence of PGE1.  PRU results may not exactly reflect findings obtained with classic ADP-induced platelet aggregation. PRU are thought to provide a measure of platelet activation mediated by the platelet P2Y12 (or ADP) receptor.  The reference range for individuals not taking drugs known to interact with this receptor is 194 - 418 PRU.  The precise significance of results above or below this range is not known.

This test may be abnormal if the patient has been treated with a Glycoprotein IIb/IIIa inhibitor within the preceding two weeks.  The manufacturer has reported no interference for patients with the following parameters:  Hematocrit values between 33 and 52%, platelet counts between 119 and 502 10 9/L, triglyceride concenterations of 41 - 824 mg/dL, cholesterol concentrations of 98 - 316 mg/dL, and fibrinogen levels between 171 and 599 mg/dL.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Administrative

CPT Codes

85576

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