Tests Catalogs

MYELIN BASIC PROTEIN

LAB190

 

Collect

CSF.

Specimen Preparation

Transport 1 mL CSF. (Min: 0.3 mL) Avoid hemolysis. If CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing the sample.

Unacceptable Conditions

Hemolysis.

Storage/Transport Temperature

Frozen.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 3 weeks (Avoid freeze/thaw cycles)

Remarks

CSF should be free from contamination with blood. Hemolysis is associated with falsely-elevated levels of MBP.

Performed

Sun-Sat

Methodology

Chemiluminescent Immunoassay

Reported

1-4 days

Synonyms

  • LAB190
  • MBP
  • MYELIN

Ordering Recommendations

Not recommended for the workup of suspected multiple sclerosis. Preferred test is Oligoclonal Band Profile (0080440).

Reference Interval

0.00-5.50 ng/mL

CPT Codes

83873
Collection

LAB190

 

Collect

CSF.

Specimen Preparation

Transport 1 mL CSF. (Min: 0.3 mL) Avoid hemolysis. If CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing the sample.

Unacceptable Conditions

Hemolysis.

Storage/Transport Temperature

Frozen.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 3 weeks (Avoid freeze/thaw cycles)

Remarks

CSF should be free from contamination with blood. Hemolysis is associated with falsely-elevated levels of MBP.
Ordering

Performed

Sun-Sat

Methodology

Chemiluminescent Immunoassay

Reported

1-4 days

Synonyms

  • LAB190
  • MBP
  • MYELIN

Ordering Recommendations

Not recommended for the workup of suspected multiple sclerosis. Preferred test is Oligoclonal Band Profile (0080440).
Result Interpretation

Reference Interval

0.00-5.50 ng/mL
Administrative

CPT Codes

83873

MYELOPEROXIDASE AB

LAB3115

 

Collect

One 7 ml red top with gel

Unacceptable Conditions

Excessive hemolysis, chylous serum, gross contamination, inadequate volume of blood, inadequate patient and/or specimen identification.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: 2 mL Separate serum from cells and deliver to the lab refrigerated.

Stability (from collection to initiation)

Refrigerated: 1-2 weeks; Frozen: Indefinitely.

Remarks

MPOAB are recomended after the PANCA and CANCA have been tested on immunofluorescence.

Performed by

PCL Clinical Laboratory

Performed

Mon - Fri

Methodology

Enzyme-linked immunosorbent assay [ELISA].

Reported

In 14 days

Synonyms

  • LAB3115
  • MPOAB
  • MYELOP

Reference Interval

0-20 units

Interpretive Data

INTERPRETATION:
0-20 units = NEGATIVE [Normal] 21-30 units = WEAK POSITIVE
>30 units = MODERATE/STRONG POSITIVE

Performed by

PCL Clinical Laboratory

CPT Codes

83876

Collection

LAB3115

 

Collect

One 7 ml red top with gel

Unacceptable Conditions

Excessive hemolysis, chylous serum, gross contamination, inadequate volume of blood, inadequate patient and/or specimen identification.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: 2 mL Separate serum from cells and deliver to the lab refrigerated.

Stability (from collection to initiation)

Refrigerated: 1-2 weeks; Frozen: Indefinitely.

Remarks

MPOAB are recomended after the PANCA and CANCA have been tested on immunofluorescence.

Performed by

PCL Clinical Laboratory

Ordering

Performed

Mon - Fri

Methodology

Enzyme-linked immunosorbent assay [ELISA].

Reported

In 14 days

Synonyms

  • LAB3115
  • MPOAB
  • MYELOP
Result Interpretation

Reference Interval

0-20 units

Interpretive Data

INTERPRETATION:
0-20 units = NEGATIVE [Normal] 21-30 units = WEAK POSITIVE
>30 units = MODERATE/STRONG POSITIVE

Performed by

PCL Clinical Laboratory

Administrative

CPT Codes

83876

MYOGLOBIN, SERUM

LAB105

 

Collect

Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin), or lavender (EDTA).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Unacceptable Conditions

Grossly hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 8 days; Refrigerated: 2 weeks; Frozen: 1 year

Performed

Sun-Sat

Methodology

Quantitative Electrochemiluminescent Immunoassay

Reported

Within 24 hours

Synonyms

  • LAB105
  • MYOG S
  • MYOGLOBIN

Ordering Recommendations

Not a standalone test. Troponin I (0090613) and Troponin T (0098803) are the recommended tests for diagnosis and management of acute coronary syndrome.

Reference Interval

Male: 28-72 ng/mL
Female: 25-58 ng/mL

CPT Codes

83874
Collection

LAB105

 

Collect

Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin), or lavender (EDTA).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Unacceptable Conditions

Grossly hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 8 days; Refrigerated: 2 weeks; Frozen: 1 year
Ordering

Performed

Sun-Sat

Methodology

Quantitative Electrochemiluminescent Immunoassay

Reported

Within 24 hours

Synonyms

  • LAB105
  • MYOG S
  • MYOGLOBIN

Ordering Recommendations

Not a standalone test. Troponin I (0090613) and Troponin T (0098803) are the recommended tests for diagnosis and management of acute coronary syndrome.
Result Interpretation

Reference Interval

Male: 28-72 ng/mL
Female: 25-58 ng/mL
Administrative

CPT Codes

83874

MYOGLOBIN, URINE

LAB412

 

Collect

Random or 24-hour urine. Refrigerate during collection.

Specimen Preparation

Thoroughly mix entire collection, then, perform one of the two processing options below:
Option 1: Immediately after collection, adjust pH to 8-9 by adding 10 percent Na2CO3. Transfer 1 mL aliquot urine to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Option 2: Immediately after collection, transfer a maximum of 4 mL urine to an ARUP Standard Transport Tube prefilled with Sodium Carbonate (ARUP)supply #48096). (Min: 0.5 mL) Available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

NaOH can also be used to adjust pH (Deliver dropwise).

Stability (from collection to initiation)

pH 8-9: Ambient: 1 hour; Refrigerated: 72 hours; Frozen: 1 month

Performed

Sun-Sat

Methodology

Quantitative Electrochemiluminescent Immunoassay

Reported

Within 24 hours

Synonyms

  • LAB412
  • MYOG-U
  • MYOGLOBIN

Reference Interval

0-1 mg/L

Interpretive Data

Patients with urine myoglobin greater than 15 mg/L are at risk of acute renal failure. Usual results are less than 1 mg/L. Results between 1 and 15 mg/L are associated with vigorous exercise, myocardial infarct, mild muscle injury, and other conditions.

CPT Codes

83874
Collection

LAB412

 

Collect

Random or 24-hour urine. Refrigerate during collection.

Specimen Preparation

Thoroughly mix entire collection, then, perform one of the two processing options below:
Option 1: Immediately after collection, adjust pH to 8-9 by adding 10 percent Na2CO3. Transfer 1 mL aliquot urine to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Option 2: Immediately after collection, transfer a maximum of 4 mL urine to an ARUP Standard Transport Tube prefilled with Sodium Carbonate (ARUP)supply #48096). (Min: 0.5 mL) Available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

NaOH can also be used to adjust pH (Deliver dropwise).

Stability (from collection to initiation)

pH 8-9: Ambient: 1 hour; Refrigerated: 72 hours; Frozen: 1 month
Ordering

Performed

Sun-Sat

Methodology

Quantitative Electrochemiluminescent Immunoassay

Reported

Within 24 hours

Synonyms

  • LAB412
  • MYOG-U
  • MYOGLOBIN
Result Interpretation

Reference Interval

0-1 mg/L

Interpretive Data

Patients with urine myoglobin greater than 15 mg/L are at risk of acute renal failure. Usual results are less than 1 mg/L. Results between 1 and 15 mg/L are associated with vigorous exercise, myocardial infarct, mild muscle injury, and other conditions.

Administrative

CPT Codes

83874

MYOSITIS ANTIBODY PANEL

LAB3705

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)

Unacceptable Conditions

Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Notes

Antibodies: Mi-2, PL-7, PL12, P155/140, EJ, Ku, OJ, PM/Scl, SRP, U2RNP, U1RNP, Ro52, Ro60, Jo-1

Performed

Mon

Methodology

Qualitative Immunoprecipitation/Semi-Quantitative Multiplex Bead Assay

Reported

5-12 days

Synonyms

  • Anti-Synthetase Antibodies
  • LAB3705
  • MYOS COMP
  • MYOSITISP
  • MYOS

Ordering Recommendations

Differential diagnosis of inflammatory myopathies in conjunction with muscle biopsy and clinical presentation. Most useful if general suspicion for inflammatory myopathy exists, including overlap syndrome.

Reference Interval

Effective May 18, 2015
Components
Reference Interval
SSA 52 and 60 (Ro) (ENA) Antibodies, IgG
ComponentsReference Interval
SSA 52 (Ro) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
SSA 60 (Ro) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive

RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Jo-1 Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Mi-2 (nuclear helicase protein) AntibodyNegative
PL-7 (threonyl-tRNA synthetase) AntibodyNegative
PL-12 (alanyl-tRNA synthetase) AntibodyNegative
P155/140 (TIF1-gamma) AntibodyNegative
EJ (glycyl-tRNA synthetase) AntibodyNegative
Ku AntibodyNegative
U2 sn (small nuclear) RNP AntibodyNegative
SRP (Signal Recognition Particle) AbNegative
OJ (isoleucyl-tRNA synthetase) AntibodyNegative
PM/Scl Complex AntibodiesNegative

Interpretive Data

Refer to individual components.

CPT Codes

83516 x10; 86235 x4
Collection

LAB3705

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)

Unacceptable Conditions

Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Notes

Antibodies: Mi-2, PL-7, PL12, P155/140, EJ, Ku, OJ, PM/Scl, SRP, U2RNP, U1RNP, Ro52, Ro60, Jo-1
Ordering

Performed

Mon

Methodology

Qualitative Immunoprecipitation/Semi-Quantitative Multiplex Bead Assay

Reported

5-12 days

Synonyms

  • Anti-Synthetase Antibodies
  • LAB3705
  • MYOS COMP
  • MYOSITISP
  • MYOS

Ordering Recommendations

Differential diagnosis of inflammatory myopathies in conjunction with muscle biopsy and clinical presentation. Most useful if general suspicion for inflammatory myopathy exists, including overlap syndrome.
Result Interpretation

Reference Interval

Effective May 18, 2015
Components
Reference Interval
SSA 52 and 60 (Ro) (ENA) Antibodies, IgG
ComponentsReference Interval
SSA 52 (Ro) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
SSA 60 (Ro) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive

RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Jo-1 Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Mi-2 (nuclear helicase protein) AntibodyNegative
PL-7 (threonyl-tRNA synthetase) AntibodyNegative
PL-12 (alanyl-tRNA synthetase) AntibodyNegative
P155/140 (TIF1-gamma) AntibodyNegative
EJ (glycyl-tRNA synthetase) AntibodyNegative
Ku AntibodyNegative
U2 sn (small nuclear) RNP AntibodyNegative
SRP (Signal Recognition Particle) AbNegative
OJ (isoleucyl-tRNA synthetase) AntibodyNegative
PM/Scl Complex AntibodiesNegative

Interpretive Data

Refer to individual components.

Administrative

CPT Codes

83516 x10; 86235 x4