URIC ACID TIMED URINE

LAB450

URIC TIMU

Collect

Timed urine collection in plastic container. 
Mandatory collection information: Start date and time and End date and time of collection.

Pediatric Collection

Timed urine collection in plastic container. Minimum volume 0.2 mL urine.

Mandatory collection information: Start date and time and End date and time of collection

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: Transport to lab at ambient temperature.

Stability (from collection to initiation)

Ambient: 3 days; Refrigerated: 7 days; Frozen (-20 degrees C): 6 months

Remarks

Requisition must state date and collection period. Indicate total collection volume when submitting an aliquot. Refrigerate during collection.

Performed by

PCL Clinical Laboratory - Core

Performed

Daily

Methodology

Enzymatic

Reported

Same day

Synonyms

  • URIC TIMU

Reference Interval

Effective 05/20/2014:

Males, 250 - 800 mg/D

Females, 250 - 750 mg/D

 

Before 05/20/2014:

Uric acid Excretion: 250 - 750 mg/Day

Performed by

PCL Clinical Laboratory - Core

CPT Codes

84560

Collection

LAB450

URIC TIMU

Collect

Timed urine collection in plastic container. 
Mandatory collection information: Start date and time and End date and time of collection.

Pediatric Collection

Timed urine collection in plastic container. Minimum volume 0.2 mL urine.

Mandatory collection information: Start date and time and End date and time of collection

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: Transport to lab at ambient temperature.

Stability (from collection to initiation)

Ambient: 3 days; Refrigerated: 7 days; Frozen (-20 degrees C): 6 months

Remarks

Requisition must state date and collection period. Indicate total collection volume when submitting an aliquot. Refrigerate during collection.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Daily

Methodology

Enzymatic

Reported

Same day

Synonyms

  • URIC TIMU
Result Interpretation

Reference Interval

Effective 05/20/2014:

Males, 250 - 800 mg/D

Females, 250 - 750 mg/D

 

Before 05/20/2014:

Uric acid Excretion: 250 - 750 mg/Day

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

84560

URIC ACID, 24 HOUR URINE

LAB4849

Collect

Timed urine collection in plastic container.
Mandatory collection information: Start date and time and End date and time of collection.
 

Pediatric Collection

Timed urine collection in plastic container. Minimum volume 0.2 mL urine.
Mandatory collection information: Start date and time and End date and time of collection.
 

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Ambient: 3 days; Refrigerated: 7 days; Frozen (-20 degrees C): 6 months.

Remarks

Requisition must state date and collection period (start time and end time). Indicate total volume when submitting an aliquot. Refrigerate during collection.

Performed by

PCL Clinical Laboratory - Core

Performed

Daily

Methodology

Enzymatic

Reported

Same day

Reference Interval

Effective 05/20/2014:

Males, 250 - 800 mg/D

Females, 250 - 750 mg/D

 

Before 05/20/2014:

Uric acid excretion: 250-750 mg/Day

Performed by

PCL Clinical Laboratory - Core

CPT Codes

84560

Collection

LAB4849

Collect

Timed urine collection in plastic container.
Mandatory collection information: Start date and time and End date and time of collection.
 

Pediatric Collection

Timed urine collection in plastic container. Minimum volume 0.2 mL urine.
Mandatory collection information: Start date and time and End date and time of collection.
 

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Ambient: 3 days; Refrigerated: 7 days; Frozen (-20 degrees C): 6 months.

Remarks

Requisition must state date and collection period (start time and end time). Indicate total volume when submitting an aliquot. Refrigerate during collection.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Daily

Methodology

Enzymatic

Reported

Same day

Result Interpretation

Reference Interval

Effective 05/20/2014:

Males, 250 - 800 mg/D

Females, 250 - 750 mg/D

 

Before 05/20/2014:

Uric acid excretion: 250-750 mg/Day

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

84560

URINALYSIS WITH REFLEX TO MICROSCOPIC EXAM (NO CULTURE REFLEX)

LAB347

UA,RFLX

Collect

Random urine, 8 mL, BD red/yellow speckled vacutainer tube.

Pediatric Collection

1 mL (performed by alternate methodology)

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; timed urine collection; frozen sample; Gray top tube (containing boric acid preservative).

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Refrigerate specimen if it cannot be transported and tested within 2 hours of collection.

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours*

*Refrigeration may precipitate crystals not originally present and may result in a lower specific gravity or alkaline pH.

Performed by

PCL Clinical Laboratory - Core

Notes

Microscopic done if dipstick is positive. If microscopic is needed also order test code MUA or -488 (UA Microscopic Required).

Performed

Upon receipt

Methodology

Reflective Photometry/Automated or manual microscopy.
Microscopic analysis performed when opacity, protein, blood, leukocyte esterase, or nitrite is positive.

Reported

Same day

Synonyms

  • LAB347
  • UA

Reference Interval

Component Sex Alpha Normal Low Normal High
APPEARANCE URINE M/F CLEAR
BILIRUBIN URINE M/F NEGATIVE
BILIRUBIN URINE, ICTOTEST M/F NEGATIVE
BLOOD URINE M/F NEGATIVE
GLUCOSE URINE C500 M/F NEGATIVE
GLUCOSE URINE IRIS M/F NEGATIVE
KETONES URINE M/F NEGATIVE
LEUKOCYTE ESTERASE URINE M/F NEGATIVE
NITRITE URINE M/F NEGATIVE
PH URINE M/F 5.0 8.0
PROTEIN URINE M/F NEGATIVE
SPECIFIC GRAVITY URINE IRIS M/F 1.001 1.035
UROBILINOGEN URINE M/F less than 2 mg/dL

Performed by

PCL Clinical Laboratory - Core

CPT Codes

81001

Collection

LAB347

UA,RFLX

Collect

Random urine, 8 mL, BD red/yellow speckled vacutainer tube.

Pediatric Collection

1 mL (performed by alternate methodology)

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; timed urine collection; frozen sample; Gray top tube (containing boric acid preservative).

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Refrigerate specimen if it cannot be transported and tested within 2 hours of collection.

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours*

*Refrigeration may precipitate crystals not originally present and may result in a lower specific gravity or alkaline pH.

Performed by

PCL Clinical Laboratory - Core

Notes

Microscopic done if dipstick is positive. If microscopic is needed also order test code MUA or -488 (UA Microscopic Required).

Ordering

Performed

Upon receipt

Methodology

Reflective Photometry/Automated or manual microscopy.
Microscopic analysis performed when opacity, protein, blood, leukocyte esterase, or nitrite is positive.

Reported

Same day

Synonyms

  • LAB347
  • UA
Result Interpretation

Reference Interval

Component Sex Alpha Normal Low Normal High
APPEARANCE URINE M/F CLEAR
BILIRUBIN URINE M/F NEGATIVE
BILIRUBIN URINE, ICTOTEST M/F NEGATIVE
BLOOD URINE M/F NEGATIVE
GLUCOSE URINE C500 M/F NEGATIVE
GLUCOSE URINE IRIS M/F NEGATIVE
KETONES URINE M/F NEGATIVE
LEUKOCYTE ESTERASE URINE M/F NEGATIVE
NITRITE URINE M/F NEGATIVE
PH URINE M/F 5.0 8.0
PROTEIN URINE M/F NEGATIVE
SPECIFIC GRAVITY URINE IRIS M/F 1.001 1.035
UROBILINOGEN URINE M/F less than 2 mg/dL

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

81001

URINALYSIS, COMPLETE (NO CULTURE REFLEX)

LAB4438

UA, COMP

 

 

Remarks

Order this test if microscopic evaluation of urine is needed regardless of UA CHEM results.

Performed by

PCL Clinical Laboratory - Core

Synonyms

  • URINE MICRO

Performed by

PCL Clinical Laboratory - Core

Collection

LAB4438

UA, COMP

 

 

Remarks

Order this test if microscopic evaluation of urine is needed regardless of UA CHEM results.

Performed by

PCL Clinical Laboratory - Core

Ordering

Synonyms

  • URINE MICRO
Result Interpretation

Performed by

PCL Clinical Laboratory - Core

Administrative

URINE CULTURE

LAB239

Collect

3-4 mL clean catch urine, single cath, indwelling cath, nephrostomy, or suprapubic aspirate in a Grey Top BD urine vacutainer tube. Source must be specified. Indicate current antibiotic therapy.

 

Also acceptable: Capped syringe with needle removed.

Pediatric Collection

0.5 ml in a sterile container (do not use BD grey Top).

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; specimen greater than 24 hours old; improper storage conditions; frozen sample; urine contaminated with feces.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: Transport to laboratory at 2-8 dgrees C if tested within 24 hours, or use urine transport tube with boric acid preservative.

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours; Urine transport tube with boric acid preservative: 24 hours; Frozen: Unacceptable.

Remarks

Gram stain is performed by request only. Cultures are held for 7 days.

Performed by

PCL Clinical Laboratory - Microbiology

Notes

Identification and susceptibility tests are billed separately from culture.

Performed

Daily

Methodology

Standard microbiology procedures for quantitative aerobic culture and identification.

Reported

Preliminary : 1 day

 

Final: Negative at 2 days.

Synonyms

  • LAB239

Reference Interval

No growth.

 

Identification and susceptibility testing will be performed according to evidence-based practices.

Performed by

PCL Clinical Laboratory - Microbiology

CPT Codes

87086

Collection

LAB239

Collect

3-4 mL clean catch urine, single cath, indwelling cath, nephrostomy, or suprapubic aspirate in a Grey Top BD urine vacutainer tube. Source must be specified. Indicate current antibiotic therapy.

 

Also acceptable: Capped syringe with needle removed.

Pediatric Collection

0.5 ml in a sterile container (do not use BD grey Top).

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; specimen greater than 24 hours old; improper storage conditions; frozen sample; urine contaminated with feces.

Storage/Transport Temperature

Internal: Deliver to lab immediately
Offsite: Transport to laboratory at 2-8 dgrees C if tested within 24 hours, or use urine transport tube with boric acid preservative.

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours; Urine transport tube with boric acid preservative: 24 hours; Frozen: Unacceptable.

Remarks

Gram stain is performed by request only. Cultures are held for 7 days.

Performed by

PCL Clinical Laboratory - Microbiology

Notes

Identification and susceptibility tests are billed separately from culture.

Ordering

Performed

Daily

Methodology

Standard microbiology procedures for quantitative aerobic culture and identification.

Reported

Preliminary : 1 day

 

Final: Negative at 2 days.

Synonyms

  • LAB239
Result Interpretation

Reference Interval

No growth.

 

Identification and susceptibility testing will be performed according to evidence-based practices.

Performed by

PCL Clinical Laboratory - Microbiology

Administrative

CPT Codes

87086

URINE DIP ONLY

LAB553

UA,CHEM

Collect

Random urine, 8 mL, red/yellow speckled BD vacutainer tube.

Pediatric Collection

1 mL urine (performed by alternate methodology)

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; timed urine collection; frozen samples; Gray top tube (containing boric acid preservative).

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours*

*Refrigeration may precipitate crystals not originally present and may result in a lower specific gravity or alkaline pH.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Reflective Photometry

Synonyms

  • LAB553
  • UA DIPSTICK

Reference Interval

Component Sex Alpha Normal Low Normal High Units
APPEARANCE URINE M/F CLEAR
BILIRUBIN URINE M/F NEGATIVE
BILIRUBIN URINE, ICTOTEST M/F NEGATIVE
BLOOD URINE M/F NEGATIVE
GLUCOSE URINE C500 M/F NEGATIVE
GLUCOSE URINE IRIS M/F NEGATIVE
KETONES URINE M/F NEGATIVE
LEUKOCYTE ESTERASE URINE M/F NEGATIVE
NITRITE URINE M/F NEGATIVE
PH URINE M/F 5.0 8.0
PROTEIN URINE M/F NEGATIVE
SPECIFIC GRAVITY URINE IRIS M/F 1.001 1.035 %
UROBILINOGEN URINE M/F less than 2 mg/dL

Performed by

PCL Clinical Laboratory - Core

CPT Codes

81003

Collection

LAB553

UA,CHEM

Collect

Random urine, 8 mL, red/yellow speckled BD vacutainer tube.

Pediatric Collection

1 mL urine (performed by alternate methodology)

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; timed urine collection; frozen samples; Gray top tube (containing boric acid preservative).

Stability (from collection to initiation)

Ambient: 2 hours; Refrigerated: 24 hours*

*Refrigeration may precipitate crystals not originally present and may result in a lower specific gravity or alkaline pH.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Reflective Photometry

Synonyms

  • LAB553
  • UA DIPSTICK
Result Interpretation

Reference Interval

Component Sex Alpha Normal Low Normal High Units
APPEARANCE URINE M/F CLEAR
BILIRUBIN URINE M/F NEGATIVE
BILIRUBIN URINE, ICTOTEST M/F NEGATIVE
BLOOD URINE M/F NEGATIVE
GLUCOSE URINE C500 M/F NEGATIVE
GLUCOSE URINE IRIS M/F NEGATIVE
KETONES URINE M/F NEGATIVE
LEUKOCYTE ESTERASE URINE M/F NEGATIVE
NITRITE URINE M/F NEGATIVE
PH URINE M/F 5.0 8.0
PROTEIN URINE M/F NEGATIVE
SPECIFIC GRAVITY URINE IRIS M/F 1.001 1.035 %
UROBILINOGEN URINE M/F less than 2 mg/dL

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

81003

URINE DRUGS OF ABUSE SCREEN

LAB3289

DOA SCN

Collect

20 mL random urine in a plastic urine container.

Larger volumes are encouraged to provide enough sample for confirmation testing, if needed.

Pediatric Collection

Minimum volume: 15 mL urine

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; paper cups; adulterated specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Transport refrigerated.

Stability (from collection to initiation)

Ambient: 2 days, Refrigerated: 7 days, Frozen: Indefinitely.

Remarks

Appropriate to order when ruling out illicit drug use/drugs of abuse as noted below:

Components with cut-offs include:
Amphetamine/Metamphetamine 1000 ng/mL
Barbituate 200 ng/mL
Benzodiazepine 200 ng/mL
Cannabinoids 50 ng/mL
Cocaine 300 ng/mL
Opiates 300 ng/mL
Phencyclidine(PCP) 25 ng/mL
Ethanol 10 mg/dL

Performed by

PCL Clinical Laboratory - Toxicology

Performed

Sun - Sat

Methodology

Homogenous Enzyme Immunoassay and Enzymatic Rate for ethanol.

Reported

Stats within 1 hour of receipt, Routines within 2 hours.

Synonyms

  • URINE TOXICOLOGY ABUSE SCREEN
  • TOX SCN
  • LAB3289
  • DOA SCN

Interpretive Data

Effective 05/20/2014:

The drugs listed in this panel are tested by immunoassay.  Definitive confirmatory testing will be performed and reported separately only for positive Barbiturates, or PCP results.  Unexpected negative screening results occur occasionally for Benzodiazepines.

SUBSTANCE (POSITIVE CUT-OFF VALUE)
Amphetamine/Methamph (1000 ng/mL)
Barbiturate (200 ng/mL)
Benzodiazepine (200 ng/mL)
Cannabinoids, THC (50 ng/mL)
Cocaine (300 ng/mL)
Opiates (300 ng/mL)
Ethanol (10 mg/dL)
Phencyclidine, PCP (25 ng/mL)

Performed by

PCL Clinical Laboratory - Toxicology

CPT Codes

80101 (8). Confirmatory testing performed using appropriate CPT code(s), if needed.

Medicare patients: G0434 (1)

Collection

LAB3289

DOA SCN

Collect

20 mL random urine in a plastic urine container.

Larger volumes are encouraged to provide enough sample for confirmation testing, if needed.

Pediatric Collection

Minimum volume: 15 mL urine

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; paper cups; adulterated specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Transport refrigerated.

Stability (from collection to initiation)

Ambient: 2 days, Refrigerated: 7 days, Frozen: Indefinitely.

Remarks

Appropriate to order when ruling out illicit drug use/drugs of abuse as noted below:

Components with cut-offs include:
Amphetamine/Metamphetamine 1000 ng/mL
Barbituate 200 ng/mL
Benzodiazepine 200 ng/mL
Cannabinoids 50 ng/mL
Cocaine 300 ng/mL
Opiates 300 ng/mL
Phencyclidine(PCP) 25 ng/mL
Ethanol 10 mg/dL

Performed by

PCL Clinical Laboratory - Toxicology

Ordering

Performed

Sun - Sat

Methodology

Homogenous Enzyme Immunoassay and Enzymatic Rate for ethanol.

Reported

Stats within 1 hour of receipt, Routines within 2 hours.

Synonyms

  • URINE TOXICOLOGY ABUSE SCREEN
  • TOX SCN
  • LAB3289
  • DOA SCN
Result Interpretation

Interpretive Data

Effective 05/20/2014:

The drugs listed in this panel are tested by immunoassay.  Definitive confirmatory testing will be performed and reported separately only for positive Barbiturates, or PCP results.  Unexpected negative screening results occur occasionally for Benzodiazepines.

SUBSTANCE (POSITIVE CUT-OFF VALUE)
Amphetamine/Methamph (1000 ng/mL)
Barbiturate (200 ng/mL)
Benzodiazepine (200 ng/mL)
Cannabinoids, THC (50 ng/mL)
Cocaine (300 ng/mL)
Opiates (300 ng/mL)
Ethanol (10 mg/dL)
Phencyclidine, PCP (25 ng/mL)

Performed by

PCL Clinical Laboratory - Toxicology

Administrative

CPT Codes

80101 (8). Confirmatory testing performed using appropriate CPT code(s), if needed.

Medicare patients: G0434 (1)

URINE TOXICOLOGY SCREEN

LAB3288

Collect

20 mL random urine in a plastic urine container.

Larger volumes are encouraged to provide enough sample for confirmation testing.

Pediatric Collection

Minimum volume: 15 mL urine

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; paper cups; adulterated specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Transport refrigerated.

Stability (from collection to initiation)

Ambient: 2 days, Refrigerated: 7 days, Frozen: Indefinitely.

Remarks

Components with cut-offs include:
Amphetamines/methamphetamine 1000 ng/mL
Barbiturates 200 ng/mL
Benzodiazepines 200ng/mL
Cannabinoids 50 ng/mL
Cocaine metabolite 300 ng/mL
Opiates 300 ng/mL
Phencyclidine (PCP) 25 ng/mL
Ethanol 10 mg/dL
Thin layer chromatography

Performed by

PCL Clinical Laboratory - Toxicology

Performed

Sun - Sat

Methodology

Homogenous enzyme immunoassay, enzymatic rate and thin layer chromatography.

Reported

Same day

Synonyms

  • LAB3288

Performed by

PCL Clinical Laboratory - Toxicology

CPT Codes

80101 (8); 80100 (2)

Collection

LAB3288

Collect

20 mL random urine in a plastic urine container.

Larger volumes are encouraged to provide enough sample for confirmation testing.

Pediatric Collection

Minimum volume: 15 mL urine

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; paper cups; adulterated specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Transport refrigerated.

Stability (from collection to initiation)

Ambient: 2 days, Refrigerated: 7 days, Frozen: Indefinitely.

Remarks

Components with cut-offs include:
Amphetamines/methamphetamine 1000 ng/mL
Barbiturates 200 ng/mL
Benzodiazepines 200ng/mL
Cannabinoids 50 ng/mL
Cocaine metabolite 300 ng/mL
Opiates 300 ng/mL
Phencyclidine (PCP) 25 ng/mL
Ethanol 10 mg/dL
Thin layer chromatography

Performed by

PCL Clinical Laboratory - Toxicology

Ordering

Performed

Sun - Sat

Methodology

Homogenous enzyme immunoassay, enzymatic rate and thin layer chromatography.

Reported

Same day

Synonyms

  • LAB3288
Result Interpretation

Performed by

PCL Clinical Laboratory - Toxicology

Administrative

CPT Codes

80101 (8); 80100 (2)

URTICARIA-INDUCED BASOPHIL ACTIVATION

LAB3127

Collect

Plain red.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Specimens other than serum. Contaminated, grossly hemolyzed, or lipemic specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediatley
Offsite: 1 mL serum Spin/separate and ship frozen.

Stability (from collection to initiation)

After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

1) Chronic urticaria (CU) is a common and complex dermatological condition that is suspected when patients experience persistent hives for over 6 weeks. No published evidence of an exogenous allergen as the cause of this disorder exists. About 45 percent of cases have autoantibodies directed against either basophil or mast cell-associated IgE or the high affinity IgE-Fc receptor (Fc epsilon R1 alpha) (Clin Exp Allergy  2009; 39: 777-87). 

2) The presence of histamine releasing factors (including but not limited to IgE and Fc epsilon R1 alpha-specific autoantibodies) in the patient serum can be indirectly determined by evaluating basophil/mast cell activation status using histamine release assays, autologous serum-skin test, and flow cytometric measurement of the basophil and mast-cell specific marker CD203c.  Serum from CU patients can activate donor basophils, which induces histamine release and CD203c upregulation (J Allergy Clin Immunol 2006; 117: 1430-4).

Performed

Mon, Fri

Methodology

Semi-Quantitative Flow Cytometry

Reported

In 2 days

Synonyms

  • FC Epsilon R1 Aantibody
  • Anti-FCe R1 Antibody
  • IGE Receptor Antibody
  • LAB3127
  • UIBA
  • ANTI-IGE RECEPTOR AB

Additional Technical Information

Ordering Recommendations

Determine whether CD203c is upregulated in suspected chronic urticaria if urticaria may be due to autoimmune antibodies to the basophil IgE receptor or to IgE.

Reference Interval

27 percent or less
27 percent or lessNegative - No basophil activation detected.
28-38 percentIndeterminate - Borderline basophil activation detected.
39 percent or greaterPositive - Basophil activation detected.

Interpretive Data

A value of 39 percent or greater suggests the presence of basophil stimulating antibodies (or other serum factors).

CPT Codes

88184; 88185 x2
Collection

LAB3127

Collect

Plain red.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Specimens other than serum. Contaminated, grossly hemolyzed, or lipemic specimens.

Storage/Transport Temperature

Internal: Deliver to lab immediatley
Offsite: 1 mL serum Spin/separate and ship frozen.

Stability (from collection to initiation)

After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

1) Chronic urticaria (CU) is a common and complex dermatological condition that is suspected when patients experience persistent hives for over 6 weeks. No published evidence of an exogenous allergen as the cause of this disorder exists. About 45 percent of cases have autoantibodies directed against either basophil or mast cell-associated IgE or the high affinity IgE-Fc receptor (Fc epsilon R1 alpha) (Clin Exp Allergy  2009; 39: 777-87). 

2) The presence of histamine releasing factors (including but not limited to IgE and Fc epsilon R1 alpha-specific autoantibodies) in the patient serum can be indirectly determined by evaluating basophil/mast cell activation status using histamine release assays, autologous serum-skin test, and flow cytometric measurement of the basophil and mast-cell specific marker CD203c.  Serum from CU patients can activate donor basophils, which induces histamine release and CD203c upregulation (J Allergy Clin Immunol 2006; 117: 1430-4).
Ordering

Performed

Mon, Fri

Methodology

Semi-Quantitative Flow Cytometry

Reported

In 2 days

Synonyms

  • FC Epsilon R1 Aantibody
  • Anti-FCe R1 Antibody
  • IGE Receptor Antibody
  • LAB3127
  • UIBA
  • ANTI-IGE RECEPTOR AB

Additional Technical Information

Ordering Recommendations

Determine whether CD203c is upregulated in suspected chronic urticaria if urticaria may be due to autoimmune antibodies to the basophil IgE receptor or to IgE.
Result Interpretation

Reference Interval

27 percent or less
27 percent or lessNegative - No basophil activation detected.
28-38 percentIndeterminate - Borderline basophil activation detected.
39 percent or greaterPositive - Basophil activation detected.

Interpretive Data

A value of 39 percent or greater suggests the presence of basophil stimulating antibodies (or other serum factors).

Administrative

CPT Codes

88184; 88185 x2

UVEITIS HLA PANEL - NON-TRANSPLANT

LAB3676

Collect

Update 10/19/15:

5 mL Purple EDTA Whole Blood. Also acceptable:

10 mL yellow top (ACD-A) whole blood

Storage/Transport Temperature

Internal: Deliver to lab immediately

External:  Deliver to lab at room temperature

Remarks

Samples should be processed at ClinImmune within 24 hours of collection. Maintain specimens at room remperature. Don not refrigerate.

Performed by

Clinimmune Labs

Performed

Upon receipt.

Methodology

HLA-A,B DR identification by low resolution technique

Synonyms

  • HLA Uveitis Panel
  • LAB3676

Performed by

Clinimmune Labs

CPT Codes

81371

Collection

LAB3676

Collect

Update 10/19/15:

5 mL Purple EDTA Whole Blood. Also acceptable:

10 mL yellow top (ACD-A) whole blood

Storage/Transport Temperature

Internal: Deliver to lab immediately

External:  Deliver to lab at room temperature

Remarks

Samples should be processed at ClinImmune within 24 hours of collection. Maintain specimens at room remperature. Don not refrigerate.

Performed by

Clinimmune Labs

Ordering

Performed

Upon receipt.

Methodology

HLA-A,B DR identification by low resolution technique

Synonyms

  • HLA Uveitis Panel
  • LAB3676
Result Interpretation

Performed by

Clinimmune Labs

Administrative

CPT Codes

81371