Tests Catalogs

DIALYSIS PANEL HD/CCPF WEEKLY (RESTRICTED TEST)

LAB3480

Collect

One 4.5 mL Green top tube with gel separator.

Also acceptable: One Red top tube with or without gel separator.

Pediatric Collection

Minimum volume: 0.2 mL plasma or serum

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Plasma: Centrifuge within 30 minutes of collection. Serum: Allow 30 minutes for serum samples to clot. Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Plasma/Serum: Ambient, 5 days; Refrigerated, 1 month; Frozen, Indefinitely

Performed by

PCL Clinical Laboratory - Core

Notes

Includes: Creatinine, BUN

THIS IS A RESTRICTED TEST-For dialysis use only

Performed

Daily

Methodology

See individual tests

Reported

Same day

Synonyms

  • LAB3480
  • HDCW

Reference Interval

See individual tests

Interpretive Data

See individual tests

Performed by

PCL Clinical Laboratory - Core

CPT Codes

See individual tests

Collection

LAB3480

Collect

One 4.5 mL Green top tube with gel separator.

Also acceptable: One Red top tube with or without gel separator.

Pediatric Collection

Minimum volume: 0.2 mL plasma or serum

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Plasma: Centrifuge within 30 minutes of collection. Serum: Allow 30 minutes for serum samples to clot. Transport to laboratory at ambient temperature.

Stability (from collection to initiation)

Plasma/Serum: Ambient, 5 days; Refrigerated, 1 month; Frozen, Indefinitely

Performed by

PCL Clinical Laboratory - Core

Notes

Includes: Creatinine, BUN

THIS IS A RESTRICTED TEST-For dialysis use only

Ordering

Performed

Daily

Methodology

See individual tests

Reported

Same day

Synonyms

  • LAB3480
  • HDCW
Result Interpretation

Reference Interval

See individual tests

Interpretive Data

See individual tests

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

See individual tests

DIGOXIN

LAB23

DIGOXIN

Collect

One 4.5 mL Green top with gel  (PST), (lithium heparin plasma).

Pediatric Collection

1.5 mL whole blood or 20 full capillary tubes.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; patient taking digitoxin or Digibind.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Centrifuge within 30 minutes of collection. Send at 2-8 degrees C. Transfer plasma to an aliquot tube and send frozen (-20 degrees C) if not assayed within 24 hours.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 24 hours; Frozen (-20 degrees C): Greater than 24 hours.

Remarks

Patients should be drawn in steady state, 5-7 days of dosing. Draw sample at least 8 hours after oral dose and 6 hours after intravenous dose.

Performed by

PCL Clinical Laboratory - Core

Performed

Upon receipt

Methodology

Chemiluminescent Immunoassay

Reported

Same day

Synonyms

  • Digitek
  • Digitalis/Digoxin
  • Lanoxin
  • Lanoxicaps
  • LAB23

Interpretive Data

The steady state therapeutic digoxin level varies from individual to individual, but is usually in the range of 1-2 ng/mL.

Performed by

PCL Clinical Laboratory - Core

CPT Codes

80162

Collection

LAB23

DIGOXIN

Collect

One 4.5 mL Green top with gel  (PST), (lithium heparin plasma).

Pediatric Collection

1.5 mL whole blood or 20 full capillary tubes.

Unacceptable Conditions

Sample not properly identified; incorrect container; insufficient sample volume; patient taking digitoxin or Digibind.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Centrifuge within 30 minutes of collection. Send at 2-8 degrees C. Transfer plasma to an aliquot tube and send frozen (-20 degrees C) if not assayed within 24 hours.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 24 hours; Frozen (-20 degrees C): Greater than 24 hours.

Remarks

Patients should be drawn in steady state, 5-7 days of dosing. Draw sample at least 8 hours after oral dose and 6 hours after intravenous dose.

Performed by

PCL Clinical Laboratory - Core

Ordering

Performed

Upon receipt

Methodology

Chemiluminescent Immunoassay

Reported

Same day

Synonyms

  • Digitek
  • Digitalis/Digoxin
  • Lanoxin
  • Lanoxicaps
  • LAB23
Result Interpretation

Interpretive Data

The steady state therapeutic digoxin level varies from individual to individual, but is usually in the range of 1-2 ng/mL.

Performed by

PCL Clinical Laboratory - Core

Administrative

CPT Codes

80162

DILUTE THROMBIN TIME

LAB5458

TT,DILUTE

Collect

One 2.7 mL blue top tube (sodium citrate).

All blue top tubes collected for coagulation assays that do not have a blood culture collected first must have a discard tube collected prior to filling.  The discard tube should be another blue top tube in which greater than 1 mL of blood is collected.

 

Pediatric Collection

Minimum volume: 0.5 mL platelet-poor plasma.

Unacceptable Conditions

Clotted sample; tube fill volume less than 90%; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Separate plasma from cells as soon as possible.  Place plasma in an aliquot container and transport to lab frozen.

Stability (from collection to initiation)

Whole blood: ambient, 4 hours.

Platelet-poor plasma: ambient, 4 hours; refrigerated, 4 hours; frozen (-20 degrees C), 2 weeks.

Remarks

The Dilute Thrombin Time (DTT) is a modification to the Thrombin Time (TT) test and is sensitive to the effects of Dabigatran, Argatroban and Bivalirudin.  A patient sample is diluted with normal plasma and tested using the thrombin time reagent.  The dilution eliminates most interferences on the assay including factor deficiencies, D-dimer, and lupus inhibitors.  Any heparin traces are diluted to a level at which only the effect on the DTT remains.  The Dilute Thrombin Time  is more sensitive than the aPTT test.

Performed by

PCL Clinical Laboratory - Coagulation

Notes

A Thrombin Time (TT) test is performed first.  If the TT results are normal, the DTT test is not needed.  If the TT results are above the normal range, the DTT is performed.

Performed

Daily

Methodology

Mechanical clot detection

Reported

Same day.

Synonyms

  • TT,DILUTE

Ordering Recommendations

The Dilute Thrombin Time (DTT) is used to confirm clearance of a direct thrombin inhibitor from the patient's plasma, typically in preparation for procedures or surgery.

Reference Interval

16.5 - 18.1 seconds

Performed by

PCL Clinical Laboratory - Coagulation

CPT Codes

85670 x 2

Collection

LAB5458

TT,DILUTE

Collect

One 2.7 mL blue top tube (sodium citrate).

All blue top tubes collected for coagulation assays that do not have a blood culture collected first must have a discard tube collected prior to filling.  The discard tube should be another blue top tube in which greater than 1 mL of blood is collected.

 

Pediatric Collection

Minimum volume: 0.5 mL platelet-poor plasma.

Unacceptable Conditions

Clotted sample; tube fill volume less than 90%; sample not properly identified; incorrect container; insufficient sample volume.

Storage/Transport Temperature

Internal: Deliver to lab immediately.

Offsite: Separate plasma from cells as soon as possible.  Place plasma in an aliquot container and transport to lab frozen.

Stability (from collection to initiation)

Whole blood: ambient, 4 hours.

Platelet-poor plasma: ambient, 4 hours; refrigerated, 4 hours; frozen (-20 degrees C), 2 weeks.

Remarks

The Dilute Thrombin Time (DTT) is a modification to the Thrombin Time (TT) test and is sensitive to the effects of Dabigatran, Argatroban and Bivalirudin.  A patient sample is diluted with normal plasma and tested using the thrombin time reagent.  The dilution eliminates most interferences on the assay including factor deficiencies, D-dimer, and lupus inhibitors.  Any heparin traces are diluted to a level at which only the effect on the DTT remains.  The Dilute Thrombin Time  is more sensitive than the aPTT test.

Performed by

PCL Clinical Laboratory - Coagulation

Notes

A Thrombin Time (TT) test is performed first.  If the TT results are normal, the DTT test is not needed.  If the TT results are above the normal range, the DTT is performed.

Ordering

Performed

Daily

Methodology

Mechanical clot detection

Reported

Same day.

Synonyms

  • TT,DILUTE

Ordering Recommendations

The Dilute Thrombin Time (DTT) is used to confirm clearance of a direct thrombin inhibitor from the patient's plasma, typically in preparation for procedures or surgery.

Result Interpretation

Reference Interval

16.5 - 18.1 seconds

Performed by

PCL Clinical Laboratory - Coagulation

Administrative

CPT Codes

85670 x 2

DIPHTHERIA ANTIBODY, IGG

LAB3151

Collect

Serum separator tube. "Pre" and "post" vaccination specimens should be submitted together for testing. "Post" specimen should be drawn 30 days after immunization.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine". If shipped separately, "Post" specimen must be received within 60 days of "Pre" specimen.

Unacceptable Conditions

Plasma or other body fluids.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Performed

Sun-Sat

Methodology

Quantitative Multiplex Bead Assay

Reported

1-2 days

Synonyms

  • LAB3151
  • DIP

Ordering Recommendations

Evaluate the ability of a patient to produce antibody to pure protein vaccine after vaccination to rule out antibody deficiency.

Reference Interval

Antibody concentration of  > 0.1 IU/mL is usually considered protective.

Interpretive Data

Responder status is determined according to the ratio of a one-month post-vaccination specimen to pre-vaccination concentration of diphtheria IgG antibody as follows:

1.  If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder.
2.  If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder.
3.  If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone.  A post-vaccination concentration above 2.5 IU in this case is usually adequate.

CPT Codes

86317
Collection

LAB3151

Collect

Serum separator tube. "Pre" and "post" vaccination specimens should be submitted together for testing. "Post" specimen should be drawn 30 days after immunization.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine". If shipped separately, "Post" specimen must be received within 60 days of "Pre" specimen.

Unacceptable Conditions

Plasma or other body fluids.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Ordering

Performed

Sun-Sat

Methodology

Quantitative Multiplex Bead Assay

Reported

1-2 days

Synonyms

  • LAB3151
  • DIP

Ordering Recommendations

Evaluate the ability of a patient to produce antibody to pure protein vaccine after vaccination to rule out antibody deficiency.
Result Interpretation

Reference Interval

Antibody concentration of  > 0.1 IU/mL is usually considered protective.

Interpretive Data

Responder status is determined according to the ratio of a one-month post-vaccination specimen to pre-vaccination concentration of diphtheria IgG antibody as follows:

1.  If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder.
2.  If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder.
3.  If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone.  A post-vaccination concentration above 2.5 IU in this case is usually adequate.

Administrative

CPT Codes

86317

DIRECT ANTIGLOBULIN TEST

Collect

One 6 mL pink top labeled with patient's last, first name, mr#, date draw, phleb initials One 5 mL purple top labeled as above.

Unacceptable Conditions

Gross hemolysis, specimen collected in a serum separator tube, specimen improperly labeled, wrong specimen container, insufficient quantity

Storage/Transport Temperature

Internal: Deliver to Blood Bank immediatley
Offsite: 1 ml Transport at room temperature within 8 hours, or refrigerated within 24 hours.

Stability (from collection to initiation)

8 hours at room temperature.

Remarks

Diagnosis and all medications received by patient before and during admission to the hospital should be indicated on requisition form. Indicate when a specimen is a cord blood.

Performed by

PCL Clinical Laboratory

Performed

Daily

Methodology

Direct Antiglobulin testing with polyspecific anti-human globulin serum and use of monospecific reagents (anti IgG, Complement) when indicated.

Reported

Same day

Synonyms

  • Direct Coombs Test

Performed by

PCL Clinical Laboratory
Collection

Collect

One 6 mL pink top labeled with patient's last, first name, mr#, date draw, phleb initials One 5 mL purple top labeled as above.

Unacceptable Conditions

Gross hemolysis, specimen collected in a serum separator tube, specimen improperly labeled, wrong specimen container, insufficient quantity

Storage/Transport Temperature

Internal: Deliver to Blood Bank immediatley
Offsite: 1 ml Transport at room temperature within 8 hours, or refrigerated within 24 hours.

Stability (from collection to initiation)

8 hours at room temperature.

Remarks

Diagnosis and all medications received by patient before and during admission to the hospital should be indicated on requisition form. Indicate when a specimen is a cord blood.

Performed by

PCL Clinical Laboratory
Ordering

Performed

Daily

Methodology

Direct Antiglobulin testing with polyspecific anti-human globulin serum and use of monospecific reagents (anti IgG, Complement) when indicated.

Reported

Same day

Synonyms

  • Direct Coombs Test
Result Interpretation

Performed by

PCL Clinical Laboratory
Administrative

DIRECT PLATELET AB - IGG/IGM

LAB1177

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 4 mL whole blood. (Min: 1 mL)

Unacceptable Conditions

Clotted, hemolyzed, frozen, or refrigerated specimens. Specimens older than 48 hours.

Storage/Transport Temperature

CRITICAL ROOM TEMPERATURE.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Remarks

Specimens must be analyzed within 48 hours of collection. Required amount of blood may be dependent on platelet count.

Notes

Detection of platelet-associated IgG and/or IgM may be used to separate thrombocytopenia of immune origin from nonimmune origin. Most patients with ITP have abnormally high levels of IgG associated with their platelets. Occasionally patients will have normal IgG levels but abnormally high levels of IgM. Dual staining and flow cytometric analysis ensures that only platelets are analyzed and relatively small volumes of blood are required. This assay does not distinguish between autoantibodies and alloantibodies, nor does it identify specific types of antiplatelet antibodies, such as those against HPA-1a. Refer to Platelet Antibodies, Indirect (ARUP test code 0051050).

Performed

Sun-Sat

Methodology

Qualitative Flow Cytometry

Reported

2-3 days

Synonyms

  • Anti-Platelet Antibodies, Direct Assay
  • LAB1177
  • PAIG

Ordering Recommendations

Support the diagnosis of autoimmune thrombocytopenia (AITP).

Reference Interval

IgG: Negative
IgM: Negative

Interpretive Data

Negative (IgG & IgM): No excess antibodies were associated with the patient's platelets. An immune cause of thrombocytopenia is unlikely.
Positive (IgG and/or IgM): An increase in platelet associated immunoglobulin is noted. An immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies.
Strong Positive (IgG and/or IgM): A definite increase in platelet associated immunoglobulin is noted and an immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies.

CPT Codes

86023 x2
Collection

LAB1177

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 4 mL whole blood. (Min: 1 mL)

Unacceptable Conditions

Clotted, hemolyzed, frozen, or refrigerated specimens. Specimens older than 48 hours.

Storage/Transport Temperature

CRITICAL ROOM TEMPERATURE.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Remarks

Specimens must be analyzed within 48 hours of collection. Required amount of blood may be dependent on platelet count.

Notes

Detection of platelet-associated IgG and/or IgM may be used to separate thrombocytopenia of immune origin from nonimmune origin. Most patients with ITP have abnormally high levels of IgG associated with their platelets. Occasionally patients will have normal IgG levels but abnormally high levels of IgM. Dual staining and flow cytometric analysis ensures that only platelets are analyzed and relatively small volumes of blood are required. This assay does not distinguish between autoantibodies and alloantibodies, nor does it identify specific types of antiplatelet antibodies, such as those against HPA-1a. Refer to Platelet Antibodies, Indirect (ARUP test code 0051050).
Ordering

Performed

Sun-Sat

Methodology

Qualitative Flow Cytometry

Reported

2-3 days

Synonyms

  • Anti-Platelet Antibodies, Direct Assay
  • LAB1177
  • PAIG

Ordering Recommendations

Support the diagnosis of autoimmune thrombocytopenia (AITP).
Result Interpretation

Reference Interval

IgG: Negative
IgM: Negative

Interpretive Data

Negative (IgG & IgM): No excess antibodies were associated with the patient's platelets. An immune cause of thrombocytopenia is unlikely.
Positive (IgG and/or IgM): An increase in platelet associated immunoglobulin is noted. An immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies.
Strong Positive (IgG and/or IgM): A definite increase in platelet associated immunoglobulin is noted and an immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies.

Administrative

CPT Codes

86023 x2

DNA - MYOTONIC DYSTOPHY TYPE 1

LAB1386

Collect

Two 5 mL purple top [EDTA] EDTA whole blood or amniotic fluid

Pediatric Collection

3 ml purple top (EDTA)

Unacceptable Conditions

Frozen samples. Serum/plasma.

Storage/Transport Temperature

Internal: Deliver to lab immediatley at room temperature
Offsite: 5 mL EDTA whole blood Deliver to lab ASAP at room temp.

Stability (from collection to initiation)

Ambient: 7-10 days. Refrigerated: 5 days.

Performed by

Baylor College of Medicine - Medical Genetics Laboratories

Performed

Mon - Fri

Methodology

Southern blot and PCR based analysis for direct detection of the myotonic dystrophy mutation.

Reported

2 - 4 weeks

Synonyms

  • DM1 DNA Test
  • -755 Myotonic Dystrophy, Type 1 DNA Test
  • Myotonic Dystrophy, Type 1 DNA Test
  • LAB1386
  • MYOTONIC DYS

Reference Interval

No mutation detected.

Performed by

Baylor College of Medicine - Medical Genetics Laboratories

CPT Codes

81401

Collection

LAB1386

Collect

Two 5 mL purple top [EDTA] EDTA whole blood or amniotic fluid

Pediatric Collection

3 ml purple top (EDTA)

Unacceptable Conditions

Frozen samples. Serum/plasma.

Storage/Transport Temperature

Internal: Deliver to lab immediatley at room temperature
Offsite: 5 mL EDTA whole blood Deliver to lab ASAP at room temp.

Stability (from collection to initiation)

Ambient: 7-10 days. Refrigerated: 5 days.

Performed by

Baylor College of Medicine - Medical Genetics Laboratories

Ordering

Performed

Mon - Fri

Methodology

Southern blot and PCR based analysis for direct detection of the myotonic dystrophy mutation.

Reported

2 - 4 weeks

Synonyms

  • DM1 DNA Test
  • -755 Myotonic Dystrophy, Type 1 DNA Test
  • Myotonic Dystrophy, Type 1 DNA Test
  • LAB1386
  • MYOTONIC DYS
Result Interpretation

Reference Interval

No mutation detected.

Performed by

Baylor College of Medicine - Medical Genetics Laboratories

Administrative

CPT Codes

81401

DNASE B ANTIBODY

LAB220

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Unacceptable Conditions

Plasma or severely hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Performed

Sun, Wed, Fri

Methodology

Quantitative Nephelometry

Reported

1-4 days

Synonyms

  • Anti-DNase-B Antibody
  • LAB220
  • DNSB

Ordering Recommendations

Confirm current or recent infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) are generally ordered concurrently. Preferred test for rheumatic chorea since it remains elevated longer.

Reference Interval

0-6 years: Less than 250 U/mL
7-17 years: Less than 310 U/mL
18 years and older: Less than 260 U/mL

CPT Codes

86215
Collection

LAB220

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Unacceptable Conditions

Plasma or severely hemolyzed specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Ordering

Performed

Sun, Wed, Fri

Methodology

Quantitative Nephelometry

Reported

1-4 days

Synonyms

  • Anti-DNase-B Antibody
  • LAB220
  • DNSB

Ordering Recommendations

Confirm current or recent infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) are generally ordered concurrently. Preferred test for rheumatic chorea since it remains elevated longer.
Result Interpretation

Reference Interval

0-6 years: Less than 250 U/mL
7-17 years: Less than 310 U/mL
18 years and older: Less than 260 U/mL
Administrative

CPT Codes

86215

DOXEPIN + METABOLITE

LAB146

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Performed

Mon, Wed, Fri

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-5 days

Synonyms

  • Sinequan
  • Adapin
  • LAB146
  • DOXEPIN

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.

Reference Interval

Effective February 19, 2013
Therapeutic RangeTotal (doxepin and nordoxepin): 100-300 ng/mL
Toxic LevelGreater than 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects and cardiac abnormalities.

CPT Codes

80335 (Alt code: G0480)
Collection

LAB146

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Ordering

Performed

Mon, Wed, Fri

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reported

1-5 days

Synonyms

  • Sinequan
  • Adapin
  • LAB146
  • DOXEPIN

Ordering Recommendations

Optimize drug therapy and monitor patient adherence.
Result Interpretation

Reference Interval

Effective February 19, 2013
Therapeutic RangeTotal (doxepin and nordoxepin): 100-300 ng/mL
Toxic LevelGreater than 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects and cardiac abnormalities.

Administrative

CPT Codes

80335 (Alt code: G0480)

DRUG DETECTION PANEL, UMBILICAL CORD, QUALITATIVE

LAB8396

Collect

at least 6 inches of umbilical cord (approximately the length of an adult hand).

Specimen Preparation

Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. Pat the cord dry and transfer specimens to the appropriate transport device or use the Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787.

Unacceptable Conditions

Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.

Storage/Transport Temperature

Chain of Custody not required/utilized.

Stability (from collection to initiation)

Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year

Notes

Absolute Minimum:  6 inches

Performed

Sun-Sat

Methodology

Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Reported

1-3 days

Synonyms

  • LAB8396
  • UMBILICAL CORD DRUG SCREEN
  • DRUG SCREEN - UMBILICAL CORD

Ordering Recommendations

Detect and document maternal drug use during approximately the last trimester of a full term birth.

Reference Interval

Effective May 16, 2016
Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine1Amphetamine5
Norbuprenorphine0.5Benzoylecgonine0.5
Buprenorphine-G1m-OH-Benzoylecgonine1
Codeine0.5Cocaethylene1
Dihydrocodeine1Cocaine0.5
Fentanyl0.5MDMA (Ecstasy)5
Hydrocodone0.5Methamphetamine5
Norhydrocodone1Phentermine8
Hydromorphone0.5Alprazolam0.5
Meperidine2Alpha-OH-Alprazolam0.5
Methadone2Butalbital25
Methadone metabolite1Clonazepam1
6-Acetylmorphine17-Aminoclonazepam1
Morphine0.5Diazepam1
Naloxone1Lorazepam5
Oxycodone0.5Midazolam1
Noroxycodone1Alpha-OH-Midazolam2
Oxymorphone0.5Nordiazepam1
Noroxymorphone0.5Oxazepam2
Propoxyphene1Phenobarbital75
Tapentadol2Temazepam1
Tramadol2Zolpidem0.5
N-desmethyltramadol2Phencyclidine (PCP)1
O-desmethyltramadol2Marijuana Metabolite1

Interpretive Data

Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.  Glucuronide metabolites are indicated as -G.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.

CPT Codes

80307
Collection
LAB8396

Collect

at least 6 inches of umbilical cord (approximately the length of an adult hand).

Specimen Preparation

Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. Pat the cord dry and transfer specimens to the appropriate transport device or use the Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787.

Unacceptable Conditions

Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.

Storage/Transport Temperature

Chain of Custody not required/utilized.

Stability (from collection to initiation)

Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year

Notes

Absolute Minimum:  6 inches
Ordering

Performed

Sun-Sat

Methodology

Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Reported

1-3 days

Synonyms

  • LAB8396
  • UMBILICAL CORD DRUG SCREEN
  • DRUG SCREEN - UMBILICAL CORD

Ordering Recommendations

Detect and document maternal drug use during approximately the last trimester of a full term birth.
Result Interpretation

Reference Interval

Effective May 16, 2016
Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine1Amphetamine5
Norbuprenorphine0.5Benzoylecgonine0.5
Buprenorphine-G1m-OH-Benzoylecgonine1
Codeine0.5Cocaethylene1
Dihydrocodeine1Cocaine0.5
Fentanyl0.5MDMA (Ecstasy)5
Hydrocodone0.5Methamphetamine5
Norhydrocodone1Phentermine8
Hydromorphone0.5Alprazolam0.5
Meperidine2Alpha-OH-Alprazolam0.5
Methadone2Butalbital25
Methadone metabolite1Clonazepam1
6-Acetylmorphine17-Aminoclonazepam1
Morphine0.5Diazepam1
Naloxone1Lorazepam5
Oxycodone0.5Midazolam1
Noroxycodone1Alpha-OH-Midazolam2
Oxymorphone0.5Nordiazepam1
Noroxymorphone0.5Oxazepam2
Propoxyphene1Phenobarbital75
Tapentadol2Temazepam1
Tramadol2Zolpidem0.5
N-desmethyltramadol2Phencyclidine (PCP)1
O-desmethyltramadol2Marijuana Metabolite1

Interpretive Data

Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.  Glucuronide metabolites are indicated as -G.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.

Administrative

CPT Codes

80307

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