LAB352
Collect
24-hour or random urine. Refrigerate 24-hour specimens during collection.
Patient Preparation
Patients should abstain, if possible, from medications, over-the-counter drugs, and herbal remedies for at least 72 hours prior to the test. Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts) and medications that may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
Specimen Preparation
Transfer 4 mL aliquot from a well-mixed 24-hour or random collection to an ARUP Standard Transport Tube. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Unacceptable Conditions
Any sample except urine.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 2 weeks
Remarks
Please see Note for a more comprehensive list of dietary restrictions.
Notes
Foods and medications associated with altered urinary HIAA results:
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, alcohol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, alcohol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Laboratories.Performed
Sun-Sat
Methodology
Quantitative High Performance Liquid Chromatography - Tandem Mass Spectrometry
Reported
1-4 days
Synonyms
- 5-HIAA, Urine
- Serotonin Metabolite, Urine
- LAB352
Ordering Recommendations
Use to diagnose carcinoid tumors and monitor disease.
Reference Interval
| Components | Reference Interval | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-HIAA Urine - per 24h | 0.0-15.0 mg/d | |||||||||||||||||||||
| 5-HIAA Urine - per volume | The HIAA-to-creatinine ratio will be reported whenever the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours. 0-14 mg/g crt | |||||||||||||||||||||
| Creatinine, Urine - per 24h |
|
Interpretive Data
5-Hydroxyindoleacetic acid (5-HIAA) results are expressed as a ratio to creatinine excretion (mg/g CRT). HIAA mass per day (mg/d) is not reported if urine collection is random, other than 24 hours, or for a urine volume less than 400 mL/d. No reference interval is available for results reported in units of mg/L. Increased urine 5-HIAA concentration is common and may be the result of improper specimen collection, consumption of serotonin containing foods or dietary supplements, drug interference, or malabsorption syndromes. Significant elevation (ten times the upper reference limit) of urine 5-HIAA may indicate the presence of a carcinoid tumor.
CPT Codes
83497
| Collection |
LAB352
Collect
24-hour or random urine. Refrigerate 24-hour specimens during collection.
Patient Preparation
Patients should abstain, if possible, from medications, over-the-counter drugs, and herbal remedies for at least 72 hours prior to the test. Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts) and medications that may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
Specimen Preparation
Transfer 4 mL aliquot from a well-mixed 24-hour or random collection to an ARUP Standard Transport Tube. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Unacceptable Conditions
Any sample except urine.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 2 weeks
Remarks
Please see Note for a more comprehensive list of dietary restrictions.
Notes
Foods and medications associated with altered urinary HIAA results:
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, alcohol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, alcohol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
| Ordering |
Performed
Sun-Sat
Methodology
Quantitative High Performance Liquid Chromatography - Tandem Mass Spectrometry
Reported
1-4 days
Synonyms
- 5-HIAA, Urine
- Serotonin Metabolite, Urine
- LAB352
Ordering Recommendations
Use to diagnose carcinoid tumors and monitor disease.
| Result Interpretation |
Reference Interval
| Components | Reference Interval | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-HIAA Urine - per 24h | 0.0-15.0 mg/d | |||||||||||||||||||||
| 5-HIAA Urine - per volume | The HIAA-to-creatinine ratio will be reported whenever the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours. 0-14 mg/g crt | |||||||||||||||||||||
| Creatinine, Urine - per 24h |
|
Interpretive Data
5-Hydroxyindoleacetic acid (5-HIAA) results are expressed as a ratio to creatinine excretion (mg/g CRT). HIAA mass per day (mg/d) is not reported if urine collection is random, other than 24 hours, or for a urine volume less than 400 mL/d. No reference interval is available for results reported in units of mg/L. Increased urine 5-HIAA concentration is common and may be the result of improper specimen collection, consumption of serotonin containing foods or dietary supplements, drug interference, or malabsorption syndromes. Significant elevation (ten times the upper reference limit) of urine 5-HIAA may indicate the presence of a carcinoid tumor.
| Administrative |
CPT Codes
83497