VOLTAGE-GATED POTASSIUM CHANNEL ANTIBODY

LAB8794

Collect

Plain red or serum separator tube.

Specimen Preparation

Separate serum from cells within 1 hour. Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Plasma. Grossly lipemic or icteric specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: Less than 72 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Performed

Tue

Methodology

Quantitative Radioimmunoassay

Reported

1-8 days

Synonyms

  • VGKC screen
  • VGKC Ab
  • VGKC complex

Additional Technical Information

Ordering Recommendations

Screening test for voltage-gated potassium channel (VGKC) antibody receptor complex-associated autoantibodies. Assay does not identify contactin associated protein 2 (CASPR2) antibody or leucine-rich glioma inactivated 1 protein (LGI1) antibodies. Use to manage antibody-positive (VGKC, LGI1, or CASPR2) individual following immunotherapy and/or plasmapheresis.

Reference Interval

Negative31 pmol/L or less
Indeterminate32-87 pmol/L
Positive88 pmol/L or greater

Interpretive Data

Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotonia (also known as Issacs syndrome) and Morvan syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated with antibodies to leucine-rich, glioma-inactivated 1 protein (Lgi1) or contactin-associated protein-2 (Caspr-2) instead of potassium channel antigens. The clinical significance of this test can only be determined in conjunction with the patient's clinical history and related laboratory testing.

CPT Codes

83519
Collection

LAB8794

Collect

Plain red or serum separator tube.

Specimen Preparation

Separate serum from cells within 1 hour. Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Unacceptable Conditions

Plasma. Grossly lipemic or icteric specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: Less than 72 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Ordering

Performed

Tue

Methodology

Quantitative Radioimmunoassay

Reported

1-8 days

Synonyms

  • VGKC screen
  • VGKC Ab
  • VGKC complex

Additional Technical Information

Ordering Recommendations

Screening test for voltage-gated potassium channel (VGKC) antibody receptor complex-associated autoantibodies. Assay does not identify contactin associated protein 2 (CASPR2) antibody or leucine-rich glioma inactivated 1 protein (LGI1) antibodies. Use to manage antibody-positive (VGKC, LGI1, or CASPR2) individual following immunotherapy and/or plasmapheresis.
Result Interpretation

Reference Interval

Negative31 pmol/L or less
Indeterminate32-87 pmol/L
Positive88 pmol/L or greater

Interpretive Data

Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotonia (also known as Issacs syndrome) and Morvan syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated with antibodies to leucine-rich, glioma-inactivated 1 protein (Lgi1) or contactin-associated protein-2 (Caspr-2) instead of potassium channel antigens. The clinical significance of this test can only be determined in conjunction with the patient's clinical history and related laboratory testing.

Administrative

CPT Codes

83519

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