VerifyNOW - ADP Reactivity

LAB5525

Collect

Two 2.0 mL blue top Greiner High Altitude BioOne Vacuette blood collection tubes using a 21 gauge needle or larger.  Fill tubes only to fill line on the label. These tubes are specially designed for this test and cannot be substituted. Order tubes in Lawson, #191357.  Lab has limited supplies and may be able to provide in an emergency.

DO NOT CENTRIFUGE. DO NOT SEND IN THE PNEUMATIC TUBE SYSTEM.

Specimen Preparation

Store at room temperature. Do not agitate samples.

Unacceptable Conditions

Sample not properly identified; incorrect containers; insufficient sample volume; tube over- or under-filled; more than 4 hours since collection; agitated sample; refrigerated or frozen samples.

Storage/Transport Temperature

Internal: Deliver to lab immediately at room temperature. Do not use pneumatic tube system or agitate tubes during delivery.

Offsite: Submission of samples from outside facilities is strongly discouraged due to high risk of sample agitation and platelet activation. See Remarks.

Stability (from collection to initiation)

Ambient temperature:  3 hours*

Remarks

*Deliver to lab as soon as possible after sample collection.  Although samples are stable for 4 hours at room temperature, allow 1 hour for lab processing and testing by sending samples to the lab no later than 3 hours after sample collection.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Performed

Daily 07:00 - 20:00

Methodology

Turbidimetric-based optical detection.

Reported

Same day

Synonyms

  • PLAVIX
  • P2Y12
  • ADP REACT

Reference Interval

194 - 418 PRU

Interpretive Data

The test results are expressed in P2Y12 Reaction Units (PRU). PRU are arbitrary units derived by the test's manufacturer and indicate the extent of ADP-induced platelet clumping of fibrinogen-coated beads in the presence of PGE1.  PRU results may not exactly reflect findings obtained with classic ADP-induced platelet aggregation. PRU are thought to provide a measure of platelet activation mediated by the platelet P2Y12 (or ADP) receptor.  The reference range for individuals not taking drugs known to interact with this receptor is 194 - 418 PRU.  The precise significance of results above or below this range is not known.

This test may be abnormal if the patient has been treated with a Glycoprotein IIb/IIIa inhibitor within the preceding two weeks.  The manufacturer has reported no interference for patients with the following parameters:  Hematocrit values between 33 and 52%, platelet counts between 119 and 502 10 9/L, triglyceride concenterations of 41 - 824 mg/dL, cholesterol concentrations of 98 - 316 mg/dL, and fibrinogen levels between 171 and 599 mg/dL.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

CPT Codes

85576

Collection

LAB5525

Collect

Two 2.0 mL blue top Greiner High Altitude BioOne Vacuette blood collection tubes using a 21 gauge needle or larger.  Fill tubes only to fill line on the label. These tubes are specially designed for this test and cannot be substituted. Order tubes in Lawson, #191357.  Lab has limited supplies and may be able to provide in an emergency.

DO NOT CENTRIFUGE. DO NOT SEND IN THE PNEUMATIC TUBE SYSTEM.

Specimen Preparation

Store at room temperature. Do not agitate samples.

Unacceptable Conditions

Sample not properly identified; incorrect containers; insufficient sample volume; tube over- or under-filled; more than 4 hours since collection; agitated sample; refrigerated or frozen samples.

Storage/Transport Temperature

Internal: Deliver to lab immediately at room temperature. Do not use pneumatic tube system or agitate tubes during delivery.

Offsite: Submission of samples from outside facilities is strongly discouraged due to high risk of sample agitation and platelet activation. See Remarks.

Stability (from collection to initiation)

Ambient temperature:  3 hours*

Remarks

*Deliver to lab as soon as possible after sample collection.  Although samples are stable for 4 hours at room temperature, allow 1 hour for lab processing and testing by sending samples to the lab no later than 3 hours after sample collection.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Ordering

Performed

Daily 07:00 - 20:00

Methodology

Turbidimetric-based optical detection.

Reported

Same day

Synonyms

  • PLAVIX
  • P2Y12
  • ADP REACT
Result Interpretation

Reference Interval

194 - 418 PRU

Interpretive Data

The test results are expressed in P2Y12 Reaction Units (PRU). PRU are arbitrary units derived by the test's manufacturer and indicate the extent of ADP-induced platelet clumping of fibrinogen-coated beads in the presence of PGE1.  PRU results may not exactly reflect findings obtained with classic ADP-induced platelet aggregation. PRU are thought to provide a measure of platelet activation mediated by the platelet P2Y12 (or ADP) receptor.  The reference range for individuals not taking drugs known to interact with this receptor is 194 - 418 PRU.  The precise significance of results above or below this range is not known.

This test may be abnormal if the patient has been treated with a Glycoprotein IIb/IIIa inhibitor within the preceding two weeks.  The manufacturer has reported no interference for patients with the following parameters:  Hematocrit values between 33 and 52%, platelet counts between 119 and 502 10 9/L, triglyceride concenterations of 41 - 824 mg/dL, cholesterol concentrations of 98 - 316 mg/dL, and fibrinogen levels between 171 and 599 mg/dL.

Performed by

PCL Clinical Laboratory - Specials (Coagulation)

Administrative

CPT Codes

85576

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