RETICULIN AB, IGA W/REFLEX

LAB773

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

IgA class reticulin antibodies are found in dermatitis herpetiformis (25%) and celiac disease (60%), but not in other autoimmune problems. IgG class reticulin antibodies are found in other disease states, especially bullous dermatoses, and sometimes in normal patients.  All positives are titered to endpoint. If Reticulin Antibody is  1:5, then a titer will be added. Additional charges apply.

Performed

Mon-Fri

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Reported

1-5 days

Synonyms

  • Anti-Reticulin Antibody, IgA
  • LAB773

Ordering Recommendations

Do not use this obsolete test for celiac disease screening. Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) for individuals with normal levels of serum IgA.

Reference Interval

Components
Reference Interval
Reticulin Ab, IgA Screen< 1:5  No antibody detected
Reticulin Antibody, IgA Titer< 1:5  No antibody detected

CPT Codes

86255; if reflexed add 86256
Collection

LAB773

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Notes

IgA class reticulin antibodies are found in dermatitis herpetiformis (25%) and celiac disease (60%), but not in other autoimmune problems. IgG class reticulin antibodies are found in other disease states, especially bullous dermatoses, and sometimes in normal patients.  All positives are titered to endpoint. If Reticulin Antibody is  1:5, then a titer will be added. Additional charges apply.
Ordering

Performed

Mon-Fri

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Reported

1-5 days

Synonyms

  • Anti-Reticulin Antibody, IgA
  • LAB773

Ordering Recommendations

Do not use this obsolete test for celiac disease screening. Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) for individuals with normal levels of serum IgA.
Result Interpretation

Reference Interval

Components
Reference Interval
Reticulin Ab, IgA Screen< 1:5  No antibody detected
Reticulin Antibody, IgA Titer< 1:5  No antibody detected

Administrative

CPT Codes

86255; if reflexed add 86256

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