RENIN ACTIVITY - PLASMA

LAB532

 

Collect

From either a supine or upright patient, Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Patient Preparation

Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Supine:
Specimen should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position).
OR
Upright:
Specimen should be obtained before noon (after at least two hours in upright position; seated or standing).
Contact Medical Director if more information is needed.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Storage/Transport Temperature

Pediatric volume = 0.6 mL EDTA plasma

Stability (from collection to initiation)

Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month

Performed

Sun-Sat

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Reported

1-2 days

Synonyms

  • Plasma Renin Activity
  • LAB532

Additional Technical Information

Ordering Recommendations

The combined aldosterone/renin tests are preferred when screening for primary hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582). Menstruating females and those taking estrogen-containing medications may have lower renin direct concentrations, resulting in falsely high ARR. In these cases, order Aldosterone/Renin Activity Ratio (0070073).  

Reference Interval

Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hrNewborn (1-7 days): 2.0-35.0 ng/mL/hr0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hrCord blood: 4.0-32.0 ng/mL/hr4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

Interpretive Data

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen.  Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

CPT Codes

84244
Collection

LAB532

 

Collect

From either a supine or upright patient, Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Patient Preparation

Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Supine:
Specimen should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position).
OR
Upright:
Specimen should be obtained before noon (after at least two hours in upright position; seated or standing).
Contact Medical Director if more information is needed.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Storage/Transport Temperature

Pediatric volume = 0.6 mL EDTA plasma

Stability (from collection to initiation)

Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month
Ordering

Performed

Sun-Sat

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Reported

1-2 days

Synonyms

  • Plasma Renin Activity
  • LAB532

Additional Technical Information

Ordering Recommendations

The combined aldosterone/renin tests are preferred when screening for primary hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582). Menstruating females and those taking estrogen-containing medications may have lower renin direct concentrations, resulting in falsely high ARR. In these cases, order Aldosterone/Renin Activity Ratio (0070073).  
Result Interpretation

Reference Interval

Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hrNewborn (1-7 days): 2.0-35.0 ng/mL/hr0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hrCord blood: 4.0-32.0 ng/mL/hr4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

Interpretive Data

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen.  Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

Administrative

CPT Codes

84244

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