RPR WITH REFLEX TO TITER

Collect

One 4.5 mL Red or Gold top tube with gel separator (SST).

Pediatric Collection

1 mL serum.

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; specimen grossly hemolyzed or lipemic.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Allow to clot for 30 minutes before centrifuging. Centrifuge within 2 hours of collection. Transport at ambient temperature if tested within 24 hours. Place serum in aliquot tube and transport frozen if not tested within 24 hours.

Stability (from collection to initiation)

Whole blood: Ambient, 1 hour; Refrigerated, 1 hour; Frozen, unacceptable.

Serum aliquot: Ambient, 24 hours; Refrigerated, 5 days; Frozen (-20 degrees C), 1 month

Remarks

RPR titer is performed on reactive samples.
Limitations: This is a nontreponemal test and is associated with false-positive reactions due to intercurrent infections, pregnancy, drug addiction, collagen-vascular diseases, and Gaucher's disease. This is a screening test for syphilis and detects antibodies to reagin. The antibodies typically develop within 4-6 weeks of inoculation, peak during the secondary phase of the disease, and then decrease. Antibodies also decrease with treatment. RPR is more sensitive than VDRL and ART. 93% of patients with primary syphilis will have positive tests. Because of the high incidence of false positive tests, any reactive serum should be further tested by a treponemal-specific test, preferably FTA-ABS. RPR should not be performed on CSF.

Performed by

PCL Clinical Laboratory - Toxicology

Performed

Monday through Friday

Methodology

Latex agglutination.

Reported

Same day

Synonyms

  • Rapid Plasma Reagin
  • -305 RPR

Reference Interval

Non Reactive

Performed by

PCL Clinical Laboratory - Toxicology

CPT Codes

86592; if reactive RPR titer will be billed 86953; if RPR Titer is reactive TP-PA 86780 will be billed.

Collection

Collect

One 4.5 mL Red or Gold top tube with gel separator (SST).

Pediatric Collection

1 mL serum.

Unacceptable Conditions

Specimen not properly identified; incorrect container; insufficient sample volume; specimen grossly hemolyzed or lipemic.

Storage/Transport Temperature

Internal: Deliver to lab immediately.
Offsite: Allow to clot for 30 minutes before centrifuging. Centrifuge within 2 hours of collection. Transport at ambient temperature if tested within 24 hours. Place serum in aliquot tube and transport frozen if not tested within 24 hours.

Stability (from collection to initiation)

Whole blood: Ambient, 1 hour; Refrigerated, 1 hour; Frozen, unacceptable.

Serum aliquot: Ambient, 24 hours; Refrigerated, 5 days; Frozen (-20 degrees C), 1 month

Remarks

RPR titer is performed on reactive samples.
Limitations: This is a nontreponemal test and is associated with false-positive reactions due to intercurrent infections, pregnancy, drug addiction, collagen-vascular diseases, and Gaucher's disease. This is a screening test for syphilis and detects antibodies to reagin. The antibodies typically develop within 4-6 weeks of inoculation, peak during the secondary phase of the disease, and then decrease. Antibodies also decrease with treatment. RPR is more sensitive than VDRL and ART. 93% of patients with primary syphilis will have positive tests. Because of the high incidence of false positive tests, any reactive serum should be further tested by a treponemal-specific test, preferably FTA-ABS. RPR should not be performed on CSF.

Performed by

PCL Clinical Laboratory - Toxicology

Ordering

Performed

Monday through Friday

Methodology

Latex agglutination.

Reported

Same day

Synonyms

  • Rapid Plasma Reagin
  • -305 RPR
Result Interpretation

Reference Interval

Non Reactive

Performed by

PCL Clinical Laboratory - Toxicology

Administrative

CPT Codes

86592; if reactive RPR titer will be billed 86953; if RPR Titer is reactive TP-PA 86780 will be billed.

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