ROCKY MOUNTAIN SPOTTED FEVER M

LAB3180

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as acute or convalescent.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Performed

Mon-Fri

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Reported

1-4 days

Synonyms

  • Rocky Mountain Spotted Fever Antibody, IgM
  • LAB3180
  • RMSF IGM

Ordering Recommendations

Detects antibodies during acute phase; paired concurrent specimen with IgG reduces false positive rate. Convalescent sera may be required for diagnosis.

Reference Interval

Less than 1:64: Negative - No significant level of Rickettsia rickettsii Antibody, IgM detected.
1:64 or greater: Positive - Presence of Rickettsia rickettsii Antibody, IgM detected, which may indicate a current or recent infection; however, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

Interpretive Data

The CDC does not use IgM results for routine diagnostic testing of Rocky Mountain Spotted Fever, as the response may not be specific for the agent (resulting in false positives) and the IgM response may be persistent from past infection.

CPT Codes

86757
Collection

LAB3180

 

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as acute or convalescent.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Ordering

Performed

Mon-Fri

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Reported

1-4 days

Synonyms

  • Rocky Mountain Spotted Fever Antibody, IgM
  • LAB3180
  • RMSF IGM

Ordering Recommendations

Detects antibodies during acute phase; paired concurrent specimen with IgG reduces false positive rate. Convalescent sera may be required for diagnosis.
Result Interpretation

Reference Interval

Less than 1:64: Negative - No significant level of Rickettsia rickettsii Antibody, IgM detected.
1:64 or greater: Positive - Presence of Rickettsia rickettsii Antibody, IgM detected, which may indicate a current or recent infection; however, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

Interpretive Data

The CDC does not use IgM results for routine diagnostic testing of Rocky Mountain Spotted Fever, as the response may not be specific for the agent (resulting in false positives) and the IgM response may be persistent from past infection.

Administrative

CPT Codes

86757

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